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Substance Name: Meldonium [INN]
RN: 76144-81-5
UNII: 73H7UDN6EC
InChIKey: PVBQYTCFVWZSJK-UHFFFAOYSA-N

Note

  • Structural analog of gamma-butyrobetaine, also of carnitine; antianginal compound; MET-88 is dihydrate.

Molecular Formula

  • C6-H14-N2-O2

Molecular Weight

  • 146.1886
 

Classification Codes

  • Adjuvants, Immunologic
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
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Names and Synonyms

Name of Substance

  • 3-(2,2,2-Trimethylhydrazine)propionate
  • Meldonium [INN]

Synonyms

  • 2-(2-Carboxyethyl)-1,1,1-trimethylhydrazinium hydroxide inner salt
  • 3-(2,2,2-Trimethyldiazaniumyl)propanoate
  • BRN 3938272
  • CCRIS 8536
  • Kvaterin
  • Meldonium
  • Mildronate
  • Quaterin
  • UNII-73H7UDN6EC

Systematic Names

  • 3-(2,2,2-Trimethylhydrazine)propionate
  • Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, hydroxide, inner salt

Registry Numbers

CAS Registry Number

  • 76144-81-5

FDA UNII

  • 73H7UDN6EC

System Generated Number

  • 0076144815

Structure Descriptors

InChI

1S/C6H14N2O2/c1-8(2,3)7-5-4-6(9)10/h7H,4-5H2,1-3H3

InChIKey

PVBQYTCFVWZSJK-UHFFFAOYSA-N

Smiles

C[N+](C)(C)NCCC(=O)[O-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD intraperitoneal > 4gm/kg (4000mg/kg)   Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
mouse LD50 intraperitoneal 7850mg/kg (7850mg/kg)   British UK Patent Application. Vol. #2105992,
mouse LD50 intravenous 4430mg/kg (4430mg/kg)   British UK Patent Application. Vol. #2105992,
mouse LD50 oral 18500mg/kg (18500mg/kg)   Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rabbit LDLo intravenous 8gm/kg (8000mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rat LD50 intraperitoneal 12gm/kg (12000mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.
rat LD50 oral > 20gm/kg (20000mg/kg)   Eksperimental'naya i Klinicheskaya Farmakoterapiya. Vol. 19, Pg. 67, 1991.