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Substance Name: Tomoxiprole [INN]
RN: 76145-76-1
UNII: EZ948T2878
InChIKey: XVDXNSRMHBAVAX-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H20-N2-O

Molecular Weight

  • 316.402
 
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Names and Synonyms

Name of Substance

  • Tomoxiprole
  • Tomoxiprole [INN]

Synonyms

  • 2-(4-Methoxyphenyl)-3-(1-methylethyl)-3H-naphth(1,2-d)imidazole
  • 3-Isopropyl-2-(p-methoxyphenyl)-3H-naphth(1,2-d)imidazole
  • BRN 5975068
  • MDL-035
  • Tomoxiprol
  • Tomoxiprol [Spanish]
  • Tomoxiprole
  • Tomoxiprolum
  • Tomoxiprolum [Latin]
  • UNII-EZ948T2878

Systematic Names

  • 3-Isopropyl-2-(p-methoxyphenyl)-3H-naphth(1,2-d)imidazole
  • 3H-Naphth(1,2-d)imidazole, 2-(4-methoxyphenyl)-3-(1-methylethyl)-

Registry Numbers

CAS Registry Number

  • 76145-76-1

FDA UNII

  • EZ948T2878

System Generated Number

  • 0076145761

Structure Descriptors

InChI

1S/C21H20N2O/c1-14(2)23-19-13-10-15-6-4-5-7-18(15)20(19)22-21(23)16-8-11-17(24-3)12-9-16/h4-14H,1-3H3

InChIKey

XVDXNSRMHBAVAX-UHFFFAOYSA-N

Smiles

CC(C)n1c2ccc3ccccc3c2nc1c4ccc(cc4)OC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 10, Pg. 133, 1985.
dog LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 10, Pg. 133, 1985.
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 10, Pg. 133, 1985.
mouse LD50 oral > 5gm/kg (5000mg/kg)   Drugs of the Future. Vol. 10, Pg. 133, 1985.
rat LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Drugs of the Future. Vol. 10, Pg. 133, 1985.
rat LD50 oral 15gm/kg (15000mg/kg)   European Journal of Drug Metabolism and Pharmacokinetics. Vol. 10, Pg. 161, 1985.