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Substance Name: Olaparib [USAN:INN]
RN: 763113-22-0
UNII: WOH1JD9AR8
InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N

Notes

  • An antineoplastic agent, Poly(ADP-ribose) Polymerase inhibitor.
  • An antineoplastic agent.

    NCI: A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. (NCI Thesaurus)

Molecular Formula

  • C24-H23-F-N4-O3

Molecular Weight

  • 434.4687
 

Classification Codes

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Poly(ADP-ribose) Polymerase Inhibitors

Names and Synonyms

Name of Substance

  • Olaparib [USAN:INN]

Synonyms

  • AZD 2281
  • AZD-2281
  • AZD221
  • AZD2281
  • KU 59436
  • KU-0059436
  • Lynparza
  • NSC 747856
  • Olaparib
  • Olaparib cpd
  • UNII-WOH1JD9AR8

Systematic Names

  • (2H)-Phthalazinone, 4-((3-((4-(cyclopropylcarbonyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-
  • 4-((3-{(4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl}-4-fluorophenyl)methyl)phthalazin-1(2H)-one

Registry Numbers

CAS Registry Number

  • 763113-22-0

FDA UNII

  • WOH1JD9AR8

Other Registry Numbers

  • 1021843-02-6
  • 894104-70-2
  • 937799-91-2

System Generated Number

  • 0763113220

Structure Descriptors

InChI

InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

InChIKey

FDLYAMZZIXQODN-UHFFFAOYSA-N

Smiles

Fc1ccc(CC2=NNC(=O)c3ccccc23)cc1C(=O)N4CCN(CC4)C(=O)C5CC5