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Substance Name: Olaparib [USAN:INN]
RN: 763113-22-0
UNII: WOH1JD9AR8
InChIKey: FDLYAMZZIXQODN-UHFFFAOYSA-N
Notes
- An antineoplastic agent, Poly(ADP-ribose) Polymerase inhibitor.
- An antineoplastic agent.
NCI: A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks. (NCI Thesaurus)
Molecular Formula
- C24-H23-F-N4-O3
Molecular Weight
- 434.4687
Classification Codes
- Antineoplastic Agents
- Enzyme Inhibitors
- Poly(ADP-ribose) Polymerase Inhibitors
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Names and Synonyms
Name of Substance
- Olaparib [USAN:INN]
Synonyms
- AZD 2281
- AZD-2281
- AZD221
- AZD2281
- KU 59436
- KU-0059436
- Lynparza
- NSC 747856
- Olaparib
- Olaparib cpd
- UNII-WOH1JD9AR8
Systematic Names
- (2H)-Phthalazinone, 4-((3-((4-(cyclopropylcarbonyl)-1-piperazinyl)carbonyl)-4-fluorophenyl)methyl)-
- 4-((3-{(4-(cyclopropylcarbonyl)piperazin-1-yl)carbonyl}-4-fluorophenyl)methyl)phthalazin-1(2H)-one
Registry Numbers
CAS Registry Number
- 763113-22-0
FDA UNII
- WOH1JD9AR8
Other Registry Numbers
- 1021843-02-6
- 894104-70-2
- 937799-91-2
System Generated Number
- 0763113220