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Substance Name: Enalaprilat
RN: 76420-72-9
UNII: Q508Q118JM
InChIKey: LZFZMUMEGBBDTC-QEJZJMRPSA-N

Note

  • The active metabolite of ENALAPRIL and a potent intravenously administered angiotensin-converting enzyme inhibitor. It is an effective agent for the treatment of essential hypertension and has beneficial hemodynamic effects in heart failure. The drug produces renal vasodilation with an increase in sodium excretion.

Molecular Formula

  • C18-H24-N2-O5

Molecular Weight

  • 348.3966
 

Classification Codes

  • Angiotensin-Converting Enzyme Inhibitors
  • Antihypertensive Agents
  • Cardiovascular Agents
  • Enzyme Inhibitors
  • Protease Inhibitors

Names and Synonyms

Results Name

  • Enalaprilat

Name of Substance

  • Enalaprilat
  • Enalaprilat anhydrous
  • Enalaprilat [INN]

Synonyms

  • EINECS 278-459-3
  • Enalapril acid
  • Enalapril diacid
  • Enalaprilat
  • Enalaprilat [Spanish]
  • Enalaprilate
  • Enalaprilate [French]
  • Enalaprilatum
  • Enalaprilatum [Latin]
  • Enalaprilic acid
  • MK 421 diacid
  • MK 422
  • N-(1(S)-Carboxy-3-phenylpropyl)-L-alanyl-L-proline
  • UNII-Q508Q118JM

Systematic Names

  • Enalaprilat
  • L-Proline, 1-(N-(1-carboxt-3-phenylpropyl)-L-alanyl)-, (S)-
  • L-Proline, N-((1S)-1-carboxy-3-phenylpropyl)-L-alanyl-

Registry Numbers

CAS Registry Number

  • 76420-72-9

FDA UNII

  • Q508Q118JM

Related Registry Number

  • 84680-54-6 (Parent)

System Generated Number

  • 0076420729

Structure Descriptors

InChI

1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1

InChIKey

LZFZMUMEGBBDTC-QEJZJMRPSA-N

Smiles

C[C@@H](C(=O)N1CCC[C@H]1C(=O)O)N[C@@H](CCc2ccccc2)C(=O)O

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 148-151 deg C   EXP
log P (octanol-water) -0.74 (none)   EXP
Water Solubility 8.940 mg/L 25 EST
Vapor Pressure 2.70E-13 mm Hg 25 EST
Henry's Law Constant 7.85E-19 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.27E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.