Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine
RN: 76684-89-4
InChIKey: SCMSYZJDIQPSDI-SRVKXCTJSA-N

Note

  • Inhibits calcium-activated neutral protease.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H26-N2-O5

Molecular Weight

  • 314.379
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine

Synonyms

  • (+)-(2S,3S)-3-((S)-3-Methyl-1-(3-methylbutylcarbamoyl)butylcarbamoyl)-2-oxiranecarboxylic acid
  • BRN 6688621
  • E 64C
  • EP 475
  • EP 475 (Enzyme inhibitor)

Systematic Names

  • Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2-alpha,3-beta(R*)))-
  • Oxiranecarboxylic acid, 3-(((3-methyl-1-(((3-methylbutyl)amino)carbonyl)butyl)amino)carbonyl)-, (2S-(2alpha,3beta(R*)))-

Registry Numbers

CAS Registry Number

  • 76684-89-4

System Generated Number

  • 0076684894

Structure Descriptors

InChI

1S/C15H26N2O5/c1-8(2)5-6-16-13(18)10(7-9(3)4)17-14(19)11-12(22-11)15(20)21/h8-12H,5-7H2,1-4H3,(H,16,18)(H,17,19)(H,20,21)/t10-,11-,12-/m0/s1

InChIKey

SCMSYZJDIQPSDI-SRVKXCTJSA-N

Smiles

O1[C@@H]([C@H]1C(=O)O)C(N[C@H](C(=O)NCCC(C)C)CC(C)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 2400mg/kg (2400mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
mouse LD50 intravenous > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
rat LD50 intraperitoneal 2140mg/kg (2140mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.
rat LD50 intravenous > 1gm/kg (1000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 17, Pg. 736, 1986.