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Substance Name: 2-Amino-5-phosphonovalerate
RN: 76726-92-6
InChIKey: VOROEQBFPPIACJ-UHFFFAOYSA-N

Note

  • The D-enantiomer is a potent and specific antagonist of NMDA glutamate receptors (RECEPTORS, N-METHYL-D-ASPARTATE). The L form is inactive at NMDA receptors but may affect the AP4 (2-amino-4-phosphonobutyrate; APB) excitatory amino acid receptors.

Molecular Formula

  • C5-H12-N-O5-P

Molecular Weight

  • 197.126
 

Classification Codes

  • Drug / Therapeutic Agent
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • 2-Amino-5-phosphonovalerate

MeSH Heading

  • 2-Amino-5-phosphonovalerate

Synonyms

  • 2-Amino-5-phosphonopentanoate
  • 2-Amino-5-phosphonovalerate
  • 5-Phosphononorvaline

Systematic Name

  • Norvaline, 5-phosphono-

Registry Numbers

CAS Registry Number

  • 76726-92-6

System Generated Number

  • 0076726926

Structure Descriptors

InChI

1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)

InChIKey

VOROEQBFPPIACJ-UHFFFAOYSA-N

Smiles

P(CCC[C@@H](C(O)=O)N)(O)(O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1030mg/kg (1030mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 37, Pg. 575, 1985.