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Substance Name: Sodium fluoride [USP:JAN]
RN: 7681-49-4
UNII: 8ZYQ1474W7
InChIKey: PUZPDOWCWNUUKD-UHFFFAOYSA-M

Note

  • A source of inorganic fluoride which is used topically to prevent dental caries.

Molecular Formulas

  • F-Na
  • Na-F

Molecular Weight

  • 41.988
 

Classification Codes

Classification Codes

  • Acaricide
  • Agricultural Chemical
  • Cariostatic Agents
  • Dental Caries Prophylactic
  • Drug / Therapeutic Agent
  • Herbicide
  • Human Data
  • Insecticide
  • Mutation Data
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Code

  • Reportable Quantity (RQ) = 1000 lb

Names and Synonyms

Name of Substance

  • Sodium fluoride
  • Sodium fluoride [USP:JAN]

MeSH Heading

  • Sodium fluoride

Synonyms

  • AI3-01500
  • Alcoa sodium fluoride
  • Antibulit
  • Apoflux
  • Caswell No. 769
  • Cavi-trol
  • CCRIS 1573
  • Chemifluor
  • Credo
  • Disodium difluoride
  • Duofluorid
  • Duraphat
  • EC 231-667-8
  • EINECS 231-667-8
  • EPA Pesticide Chemical Code 075202
  • Ethedent
  • F1-Tabs
  • FDA 0101
  • Floridine
  • Florocid
  • Flozenges
  • Fludent
  • Fluonatril
  • Fluor-O-kote
  • Fluoraday
  • Fluoral
  • Fluorid sodny
  • Fluorid sodny [Czech]
  • Fluoride, sodium
  • Fluorident
  • Fluorigard
  • Fluorineed
  • Fluorinse
  • Fluoritab
  • Fluorocid
  • Fluorol
  • Fluorure de sodium
  • Fluorure de sodium [French]
  • Fluorure de sodium [ISO-French]
  • Flura
  • Flura drops
  • Flura-gel
  • Flura-loz
  • Flurcare
  • Flurexal
  • Flursol
  • Flux
  • Fungol B
  • GEL II
  • Gelution
  • Gleem
  • HSDB 1766
  • Iradicav
  • Kari-rinse
  • Karidium
  • Karigel
  • Koreberon
  • Lea-Cov
  • Lemoflur
  • Les-Cav
  • Liquiflur
  • Luride
  • Luride lozi-tabs
  • Luride SF
  • Luride-SF
  • Minute-Gel
  • Na frinse
  • Nafeen
  • NaFpak
  • Natrium fluoride
  • NCI-C55221
  • Neutra Care
  • NSC 77385
  • Nufluor
  • Ossalin
  • Ossin
  • Osteopor-F
  • Pediaflor
  • Pedident
  • Pennwhite
  • Pergantene
  • Phos-Flur
  • Point two
  • Predent
  • Prevident 5000 Plus
  • Rafluor
  • Rescue squad
  • Roach salt
  • SO-Flo
  • Sodium flouride
  • Sodium fluoride
  • Sodium fluoride (Na2F2)
  • Sodium fluoride (NaF)
  • Sodium fluoride cyclic dimer
  • Sodium fluoride [ISO]
  • Sodium fluoride, solid (DOT)
  • Sodium fluorure
  • Sodium fluorure [French]
  • Sodium hydrofluoride
  • Sodium monofluoride
  • Stay-Flo
  • Studafluor
  • Super-dent
  • T-Fluoride
  • Thera-flur
  • Thera-flur-N
  • Trisodium trifluoride
  • UNII-8ZYQ1474W7
  • Villiaumite
  • Xaridium
  • Zooby
  • Zymafluor

Systematic Names

  • Sodium fluoride
  • Sodium fluoride (NaF)

Superlist Names

  • Sodium fluoride
  • Sodium fluoride [UN1690] [Poison]
  • UN1690

Mixture Names

  • Fluor-a-day
  • Sensodyne

Registry Numbers

CAS Registry Number

  • 7681-49-4

FDA UNII

  • 8ZYQ1474W7

Other Registry Numbers

  • 2018280-11-8
  • 39287-69-9
  • 59217-75-3
  • 67112-29-2

Related Registry Number

  • 1333-83-1 (hydrochloride(HF2))

System Generated Number

  • 0007681494

Structure Descriptors

InChI

1S/FH.Na/h1H;/q;+1/p-1

InChIKey

PUZPDOWCWNUUKD-UHFFFAOYSA-M

Smiles

[Na+].[FH-]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
bird - wild LD50 oral 110mg/kg (110mg/kg)   Archives of Environmental Contamination and Toxicology. Vol. 16, Pg. 483, 1987.
cat LDLo subcutaneous 14mg/kg (14mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
dog LDLo intraperitoneal 50mg/kg (50mg/kg)   U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951,
dog LDLo subcutaneous 155mg/kg (155mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
domestic animals - goat/sheep LD50 oral 100mg/kg (100mg/kg)   New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982.
domestic animals - goat/sheep LD50 oral 100mg/kg (100mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)		 New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982.
frog LDLo subcutaneous 448mg/kg (448mg/kg)   Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 124, Pg. 133, 1937.
guinea pig LDLo subcutaneous 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
human LDLo oral 71mg/kg (71mg/kg) BEHAVIORAL: TREMOR

MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES

MUSCULOSKELETAL: OTHER CHANGES		 "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1361, 1989.
human LDLo oral 75mg/kg (75mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1033, 1966.
human TDLo intradermal 14ug/kg (0.014mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE		 Revue Medicale de Liege. Vol. 12, Pg. 408, 1957.
human TDLo oral 214ug/kg (0.214mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: HEADACHE

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Revue Medicale de Liege. Vol. 12, Pg. 408, 1957.
man TDLo oral 1662mg/kg (1662mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: NAUSEA OR VOMITING

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE		 JAMA, Journal of the American Medical Association. Vol. 222, Pg. 816, 1972.
monkey LD50 intravenous 26600ug/kg (26.6mg/kg)   Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 99, 1965.
mouse LD50 intraperitoneal 38mg/kg (38mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES		 IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.
mouse LD50 intravenous 50830ug/kg (50.83mg/kg) GASTROINTESTINAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: OTHER CHANGES

LIVER: OTHER CHANGES		 IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982.
mouse LD50 oral 57mg/kg (57mg/kg)   Shika Gakuho. Journal of Dentistry. Vol. 80, Pg. 1519, 1980.
mouse LD50 subcutaneous 115ug/kg (0.115mg/kg)   Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68(3), Pg. 55P-74P, 1972.
mouse LDLo skin 300mg/kg (300mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 183, Pg. 427, 1936.
rabbit LD50 oral 200mg/kg (200mg/kg)   Journal of Economic Entomology. Vol. 61, Pg. 751, 1968.
rabbit LDLo subcutaneous 100mg/kg (100mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935.
rat LD50 intraperitoneal 22mg/kg (22mg/kg)   U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951,
rat LD50 intravenous 26mg/kg (26mg/kg) SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE		 Toxicology and Applied Pharmacology. Vol. 3, Pg. 278, 1961.
rat LD50 oral 52mg/kg (52mg/kg)   National Technical Information Service. Vol. UR-3490-95,
rat LD50 subcutaneous 175mg/kg (175mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968.
women LDLo oral 90mg/kg (90mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: FLUID INTAKE

BEHAVIORAL: MUSCLE WEAKNESS		 JAMA, Journal of the American Medical Association. Vol. 81, Pg. 811, 1923.
women LDLo oral 360mg/kg (360mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 JAMA, Journal of the American Medical Association. Vol. 100, Pg. 97, 1933.
women TDLo oral 7mg/kg (7mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE		 British Medical Journal. Vol. 1, Pg. 886, 1936.