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Substance Name: Sodium fluoride [USP:JAN]
RN: 7681-49-4
UNII: 8ZYQ1474W7
InChIKey: PUZPDOWCWNUUKD-UHFFFAOYSA-M
Note
- A source of inorganic fluoride which is used topically to prevent dental caries.
Molecular Formulas
- F-Na
- Na-F
Molecular Weight
- 41.988
Classification Codes
Classification Codes
- Acaricide
- Agricultural Chemical
- Cariostatic Agents
- Dental Caries Prophylactic
- Drug / Therapeutic Agent
- Herbicide
- Human Data
- Insecticide
- Mutation Data
- Protective Agents
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Code
- Reportable Quantity (RQ) = 1000 lb
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Names and Synonyms
Name of Substance
- Sodium fluoride
- Sodium fluoride [USP:JAN]
MeSH Heading
- Sodium fluoride
Synonyms
- AI3-01500
- Alcoa sodium fluoride
- Antibulit
- Apoflux
- Caswell No. 769
- Cavi-trol
- CCRIS 1573
- Chemifluor
- Credo
- Disodium difluoride
- Duofluorid
- Duraphat
- EC 231-667-8
- EINECS 231-667-8
- EPA Pesticide Chemical Code 075202
- Ethedent
- F1-Tabs
- FDA 0101
- Floridine
- Florocid
- Flozenges
- Fludent
- Fluonatril
- Fluor-O-kote
- Fluoraday
- Fluoral
- Fluorid sodny
- Fluorid sodny [Czech]
- Fluoride, sodium
- Fluorident
- Fluorigard
- Fluorineed
- Fluorinse
- Fluoritab
- Fluorocid
- Fluorol
- Fluorure de sodium
- Fluorure de sodium [French]
- Fluorure de sodium [ISO-French]
- Flura
- Flura drops
- Flura-gel
- Flura-loz
- Flurcare
- Flurexal
- Flursol
- Flux
- Fungol B
- GEL II
- Gelution
- Gleem
- HSDB 1766
- Iradicav
- Kari-rinse
- Karidium
- Karigel
- Koreberon
- Lea-Cov
- Lemoflur
- Les-Cav
- Liquiflur
- Luride
- Luride lozi-tabs
- Luride SF
- Luride-SF
- Minute-Gel
- Na frinse
- Nafeen
- NaFpak
- Natrium fluoride
- NCI-C55221
- Neutra Care
- NSC 77385
- Nufluor
- Ossalin
- Ossin
- Osteopor-F
- Pediaflor
- Pedident
- Pennwhite
- Pergantene
- Phos-Flur
- Point two
- Predent
- Prevident 5000 Plus
- Rafluor
- Rescue squad
- Roach salt
- SO-Flo
- Sodium flouride
- Sodium fluoride
- Sodium fluoride (Na2F2)
- Sodium fluoride (NaF)
- Sodium fluoride cyclic dimer
- Sodium fluoride [ISO]
- Sodium fluoride, solid (DOT)
- Sodium fluorure
- Sodium fluorure [French]
- Sodium hydrofluoride
- Sodium monofluoride
- Stay-Flo
- Studafluor
- Super-dent
- T-Fluoride
- Thera-flur
- Thera-flur-N
- Trisodium trifluoride
- UNII-8ZYQ1474W7
- Villiaumite
- Xaridium
- Zooby
- Zymafluor
Systematic Names
- Sodium fluoride
- Sodium fluoride (NaF)
Superlist Names
- Sodium fluoride
- Sodium fluoride [UN1690] [Poison]
- UN1690
Mixture Names
- Fluor-a-day
- Sensodyne
Registry Numbers
CAS Registry Number
- 7681-49-4
FDA UNII
- 8ZYQ1474W7
Other Registry Numbers
- 2018280-11-8
- 39287-69-9
- 59217-75-3
- 67112-29-2
Related Registry Number
- 1333-83-1 (hydrochloride(HF2))
System Generated Number
- 0007681494
Structure Descriptors
InChI
InChI=1S/FH.Na/h1H;/q;+1/p-1InChIKey
PUZPDOWCWNUUKD-UHFFFAOYSA-MSmiles
[F-].[Na+]Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
bird - wild | LD50 | oral | 110mg/kg (110mg/kg) | Archives of Environmental Contamination and Toxicology. Vol. 16, Pg. 483, 1987. | |
cat | LDLo | subcutaneous | 14mg/kg (14mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935. | |
dog | LDLo | intraperitoneal | 50mg/kg (50mg/kg) | U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951, | |
dog | LDLo | subcutaneous | 155mg/kg (155mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935. | |
domestic animals - goat/sheep | LD50 | oral | 100mg/kg (100mg/kg) | New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982. | |
domestic animals - goat/sheep | LD50 | oral | 100mg/kg (100mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | New Zealand Veterinary Journal. Vol. 30, Pg. 199, 1982. |
frog | LDLo | subcutaneous | 448mg/kg (448mg/kg) | Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. Vol. 124, Pg. 133, 1937. | |
guinea pig | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935. | |
human | LDLo | oral | 71mg/kg (71mg/kg) | BEHAVIORAL: TREMOR MUSCULOSKELETAL: CHANGES IN TEETH AND SUPPORTING STRUCTURES MUSCULOSKELETAL: OTHER CHANGES | "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 1361, 1989. |
human | LDLo | oral | 75mg/kg (75mg/kg) | Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 1033, 1966. | |
human | TDLo | intradermal | 14ug/kg (0.014mg/kg) | PERIPHERAL NERVE AND SENSATION: PARESTHESIS IMMUNOLOGICAL INCLUDING ALLERGIC: INCREASED IMMUNE RESPONSE | Revue Medicale de Liege. Vol. 12, Pg. 408, 1957. |
human | TDLo | oral | 214ug/kg (0.214mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: HEADACHE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Revue Medicale de Liege. Vol. 12, Pg. 408, 1957. |
man | TDLo | oral | 1662mg/kg (1662mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION GASTROINTESTINAL: NAUSEA OR VOMITING CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE | JAMA, Journal of the American Medical Association. Vol. 222, Pg. 816, 1972. |
monkey | LD50 | intravenous | 26600ug/kg (26.6mg/kg) | Acta Pharmacologica et Toxicologica. Vol. 22, Pg. 99, 1965. | |
mouse | LD50 | intraperitoneal | 38mg/kg (38mg/kg) | GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982. |
mouse | LD50 | intravenous | 50830ug/kg (50.83mg/kg) | GASTROINTESTINAL: OTHER CHANGES KIDNEY, URETER, AND BLADDER: OTHER CHANGES LIVER: OTHER CHANGES | IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. Vol. 27, Pg. 237, 1982. |
mouse | LD50 | oral | 57mg/kg (57mg/kg) | Shika Gakuho. Journal of Dentistry. Vol. 80, Pg. 1519, 1980. | |
mouse | LD50 | subcutaneous | 115ug/kg (0.115mg/kg) | Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 68(3), Pg. 55P-74P, 1972. | |
mouse | LDLo | skin | 300mg/kg (300mg/kg) | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 183, Pg. 427, 1936. | |
rabbit | LD50 | oral | 200mg/kg (200mg/kg) | Journal of Economic Entomology. Vol. 61, Pg. 751, 1968. | |
rabbit | LDLo | subcutaneous | 100mg/kg (100mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1349, 1935. | |
rat | LD50 | intraperitoneal | 22mg/kg (22mg/kg) | U.S. Atomic Energy Commission, University of Rochester, Research and Development Reports. Vol. UR-154, Pg. 1951, | |
rat | LD50 | intravenous | 26mg/kg (26mg/kg) | SENSE ORGANS AND SPECIAL SENSES: TUMORS: OLFACTION SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE | Toxicology and Applied Pharmacology. Vol. 3, Pg. 278, 1961. |
rat | LD50 | oral | 52mg/kg (52mg/kg) | National Technical Information Service. Vol. UR-3490-95, | |
rat | LD50 | subcutaneous | 175mg/kg (175mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 2, Pg. 411, 1968. | |
women | LDLo | oral | 90mg/kg (90mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: FLUID INTAKE BEHAVIORAL: MUSCLE WEAKNESS | JAMA, Journal of the American Medical Association. Vol. 81, Pg. 811, 1923. |
women | LDLo | oral | 360mg/kg (360mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | JAMA, Journal of the American Medical Association. Vol. 100, Pg. 97, 1933. |
women | TDLo | oral | 7mg/kg (7mg/kg) | LUNGS, THORAX, OR RESPIRATION: CYANOSIS SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | British Medical Journal. Vol. 1, Pg. 886, 1936. |