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Substance Name: Indomethacin sodium
RN: 7681-54-1
UNII: 1C9D998830
InChIKey: JMHRGKDWGWORNU-UHFFFAOYSA-M

Note

  • A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.

Molecular Formulas

  • C19-H15-Cl-N-O4.Na
  • C19-H16-Cl-N-O4.Na

Molecular Weight

  • 379.7735
 

Classification Code

  • Drug / Therapeutic Agent

Names and Synonyms

Results Name

  • Indomethacin sodium

Name of Substance

  • Indomethacin sodium anhydrous

Synonyms

  • EINECS 231-670-4
  • Indocin I.V.
  • Indomethacin sodium
  • Osmosin
  • Sodium 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate
  • Sodium indomethacin
  • UNII-1C9D998830

Systematic Names

  • 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt
  • Indole-3-acetic acid, 1-(p-chlorobenzoyl)-5-methoxy-2-methyl-, sodium salt (8CI)
  • Sodium 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetate

Registry Numbers

CAS Registry Number

  • 7681-54-1

FDA UNII

  • 1C9D998830

Related Registry Number

  • 53-86-1 (Parent)

System Generated Number

  • 0007681541

Molecular Formulas

Molecular Formulas

  • C19-H15-Cl-N-O4.Na
  • C19-H16-Cl-N-O4.Na

Molecular Formula Fragments

  • C19-H15-Cl-N-O4
  • C19-H16-Cl-N-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C19H16ClNO4.Na/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12;/h3-9H,10H2,1-2H3,(H,22,23);/q;+1/p-1

InChIKey

JMHRGKDWGWORNU-UHFFFAOYSA-M

Smiles

Cc1c(c2cc(ccc2n1C(=O)c3ccc(cc3)Cl)OC)CC(=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 266mg/kg (266mg/kg)   Pharmaceutical Sciences. Vol. 3, Pg. 203, 1997.