Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Famotidine [USAN:USP:INN:BAN:JAN]
RN: 76824-35-6
UNII: 5QZO15J2Z8
InChIKey: XUFQPHANEAPEMJ-UHFFFAOYSA-N

Note

  • A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Molecular Formula

  • C8-H15-N7-O2-S3

Molecular Weight

  • 337.4515
 

Classification Codes

  • Antagonist
  • Antagonist (to Histamine H2 Receptors)
  • Anti-Ulcer Agents
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H2 Antagonists
  • Human Data
  • Neurotransmitter Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Famotidine
  • Famotidine [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Famotidine

Synonyms

  • (1-Amino-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propylidene)sulfamide
  • 3-(((2-((Aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)propanimidamide
  • 3-(((2-((Diaminomethylene)amino)-4-thiazolyl)methyl)thio)-N(sup 2)-sulfamoylpropionamidine
  • Acid reducer
  • Amfamox
  • Antodine
  • Apo-Famotidine
  • Apogastine
  • Bestidine
  • Blocacid
  • Brolin
  • Cepal
  • Confobos
  • Cronol
  • Cuantin
  • Dibrit 40
  • Digervin
  • Dinul
  • Dipsin
  • Dispromil
  • Dispronil
  • Duovel
  • Durater
  • Evatin
  • Fadin
  • Fadine
  • Fadyn
  • Fagastine
  • Famo
  • Famocid
  • Famodar
  • Famodil
  • Famodin
  • Famodine
  • Famogard
  • Famonit
  • Famopsin
  • Famos
  • Famosan
  • Famotal
  • Famotep
  • Famotidina
  • Famotidina [Spanish]
  • Famotidine
  • Famotidine preservative free
  • Famotidine preservative free (pharmacy bulk)
  • Famotidine preservative free in plastic container
  • Famotidinum
  • Famotidinum [Latin]
  • Famotin
  • Famovane
  • Famowal
  • Famox
  • Famoxal
  • Famtac
  • Famulcer
  • Fanobel
  • Fanosin
  • Fanox
  • Farmotex
  • Ferotine
  • Fibonel
  • Fluxid
  • Fudone
  • Ganor
  • Gaster
  • Gastridan
  • Gastridin
  • Gastrion
  • Gastro
  • Gastrodomina
  • Gastrofam
  • Gastropen
  • Gastrosidin
  • H2 Bloc
  • Hacip
  • HSDB 3572
  • Huberdina
  • Ingastri
  • Invigan
  • L 643341
  • Lecedil
  • Logos
  • Major heartburn relief
  • Mensoma
  • Midefam
  • MK 208
  • MK-208
  • Mosul
  • Motiax
  • Muclox
  • Mylanta AR
  • N-Sulfamoyl-3-((2-guanidinothiazol-4-yl)methylthio)propionamide
  • Neocidine
  • Nevofam
  • Notidin
  • Novo-Famotidine
  • Nu-Famotidine
  • Nulceran
  • Nulcerin
  • Panalba
  • Pepcid
  • Pepcid AC
  • Pepcid AC (geltab)
  • Pepcid preservative free
  • Pepcid preservative free in plastic container
  • Pepcid RPD
  • Pepcidac
  • Pepcidin
  • Pepcidin Rapitab
  • Pepcidina
  • Pepcidine
  • Pepdif
  • Pepdine
  • Pepdul
  • Pepfamin
  • Peptan
  • Peptidin
  • Peptifam
  • Pepzan
  • Purifam
  • Quamatel
  • Quamtel
  • Renapepsa
  • Restadin
  • Rogasti
  • Rubacina
  • Sedanium-R
  • Sigafam
  • Supertidine
  • Tairal
  • Tamin
  • Tipodex
  • Topcid
  • Ulcatif
  • Ulceprax
  • Ulcofam
  • Ulfagel
  • Ulfam
  • Ulfamid
  • Ulfinol
  • Ulgarine
  • UNII-5QZO15J2Z8
  • Vagostal
  • Weimok
  • Whitidin
  • Yamarin
  • YM 11170
  • YM-11170

Systematic Names

  • Propanimidamide, 3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-N-(aminosulfonyl)-
  • Propanimidamide, N'-(aminosulfonyl)-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)-

Registry Numbers

CAS Registry Number

  • 76824-35-6

FDA UNII

  • 5QZO15J2Z8

Related Registry Number

  • 108885-67-2 (HCl)

System Generated Number

  • 0076824356

Structure Descriptors

InChI

1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)

InChIKey

XUFQPHANEAPEMJ-UHFFFAOYSA-N

Smiles

c1c(nc(s1)N=C(N)N)CSCC/C(=N\S(=O)(=O)N)/N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 4mg/kg/7D-I (4mg/kg)   Annals of Pharmacotherpy. Vol. 28, Pg. 40, 1994.
man TDLo oral 209mg/kg/1Y-I (209mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE American Journal of Medicine. Vol. 108, Pg. 438, 2000.
mouse LD50 intraperitoneal 778mg/kg (778mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Oyo Yakuri. Pharmacometrics. Vol. 26, Pg. 147, 1983.
mouse LD50 intravenous 254mg/kg (254mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 590, 1985.
mouse LD50 oral 4686mg/kg (4686mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 16, Pg. 590, 1985.
mouse LD50 subcutaneous 800mg/kg (800mg/kg)   Digestion. Vol. 32(Suppl,
rat LD50 intraperitoneal 800mg/kg (800mg/kg)   Digestion. Vol. 32(Suppl,
rat LD50 intravenous 204mg/kg (204mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 6125, 1984.
rat LD50 oral 4049mg/kg (4049mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 19, Pg. 544, 1988.
rat LD50 subcutaneous 800mg/kg (800mg/kg)   Digestion. Vol. 32(Suppl,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 163.5 deg C   EXP
log P (octanol-water) -0.64 (none)   EXP
Water Solubility 1000 mg/L 20 EXP
Vapor Pressure 6.02E-11 mm Hg 25 EST
Henry's Law Constant 5.44E-24 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 8.62E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.