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Substance Name: Nizatidine [USAN:USP:INN:BAN:JAN]
RN: 76963-41-2
UNII: P41PML4GHR
InChIKey: SGXXNSQHWDMGGP-UHFFFAOYSA-N
Note
- A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.
Molecular Formula
- C12-H21-N5-O2-S2
Molecular Weight
- 331.4629
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- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Ulcer Agents
- Anti-Ulcerative
- Drug / Therapeutic Agent
- Gastrointestinal Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H2 Antagonists
- Neurotransmitter Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Nizatidine
- Nizatidine [USAN:USP:INN:BAN:JAN]
MeSH Heading
- Nizatidine
Synonyms
- 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazoly)methyl)thio)ethyl)-N'-methyl-2-nitro-
- 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
- Acinon
- Antizid
- Axid
- Axid AR
- BRN 4846056
- Calmaxid
- Cronizat
- Distaxid
- Galitidin
- Gastrax
- HSDB 3574
- LY 139037
- N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
- N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin
- Naxidine
- Nizatidina
- Nizatidina [Spanish]
- Nizatidine
- Nizatidinum
- Nizatidinum [Latin]
- Nizax
- Nizaxid
- Panaxid
- Splendil ER
- Tazac
- Ulcosol
- Ulxid
- UNII-P41PML4GHR
- Zanizal
- ZE-101
- Zinga
- ZL-101
Systematic Name
- 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
Registry Numbers
CAS Registry Number
- 76963-41-2
FDA UNII
- P41PML4GHR
System Generated Number
- 0076963412
Structure Descriptors
InChI
InChI=1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3InChIKey
SGXXNSQHWDMGGP-UHFFFAOYSA-NSmiles
CNC(=C[N+](=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| dog | LD50 | intramuscular | > 225mg/kg (225mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: TETANY BEHAVIORAL: TREMOR | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| dog | LD50 | intravenous | > 75mg/kg (75mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: TREMOR | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| dog | LD50 | oral | > 800mg/kg (800mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| monkey | LD50 | intravenous | > 200mg/kg (200mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| monkey | LD50 | oral | > 1200mg/kg (1200mg/kg) | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. | |
| mouse | LD50 | intravenous | 232mg/kg (232mg/kg) | Drugs in Japan Vol. -, Pg. 920, 1995. | |
| mouse | LD50 | oral | 1630mg/kg (1630mg/kg) | Drugs in Japan Vol. -, Pg. 920, 1995. | |
| mouse | LD50 | subcutaneous | 1082mg/kg (1082mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| rat | LD50 | intravenous | 301mg/kg (301mg/kg) | BEHAVIORAL: COMA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
| rat | LD50 | oral | 1653mg/kg (1653mg/kg) | Drugs in Japan Vol. -, Pg. 920, 1995. | |
| rat | LD50 | subcutaneous | > 2gm/kg (2000mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" BEHAVIORAL: COMA | Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 130-132 | deg C | EXP | |
| log P (octanol-water) | -0.430 | (none) | EST | |
| Atmospheric OH Rate Constant | 2.44E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.