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Substance Name: Nizatidine [USAN:USP:INN:BAN:JAN]
RN: 76963-41-2
UNII: P41PML4GHR
InChIKey: SGXXNSQHWDMGGP-UHFFFAOYSA-N

Note

  • A histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. The drug is used for the treatment of duodenal ulcers.

Molecular Formula

  • C12-H21-N5-O2-S2

Molecular Weight

  • 331.4629
 

Classification Codes

  • Anti-Ulcer Agents
  • Anti-Ulcerative
  • Drug / Therapeutic Agent
  • Gastrointestinal Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H2 Antagonists
  • Neurotransmitter Agents
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Nizatidine
  • Nizatidine [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Nizatidine

Synonyms

  • 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazoly)methyl)thio)ethyl)-N'-methyl-2-nitro-
  • 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-
  • Acinon
  • Antizid
  • Axid
  • Axid AR
  • BRN 4846056
  • Calmaxid
  • Cronizat
  • Distaxid
  • Galitidin
  • Gastrax
  • HSDB 3574
  • LY 139037
  • N-(2-(((2-((Dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-1,1-ethenediamine
  • N-(4-(6-Methylamino-7-nitro-2-thia-5-aza-6-hepten-1-yl)-2-thiazolylmethyl)-N,N-dimethylamin
  • Naxidine
  • Nizatidina
  • Nizatidina [Spanish]
  • Nizatidine
  • Nizatidinum
  • Nizatidinum [Latin]
  • Nizax
  • Nizaxid
  • Panaxid
  • Splendil ER
  • Tazac
  • Ulcosol
  • Ulxid
  • UNII-P41PML4GHR
  • Zanizal
  • ZE-101
  • Zinga
  • ZL-101

Systematic Name

  • 1,1-Ethenediamine, N-(2-(((2-((dimethylamino)methyl)-4-thiazolyl)methyl)thio)ethyl)-N'-methyl-2-nitro-

Registry Numbers

CAS Registry Number

  • 76963-41-2

FDA UNII

  • P41PML4GHR

System Generated Number

  • 0076963412

Structure Descriptors

InChI

1S/C12H21N5O2S2/c1-13-11(6-17(18)19)14-4-5-20-8-10-9-21-12(15-10)7-16(2)3/h6,9,13-14H,4-5,7-8H2,1-3H3

InChIKey

SGXXNSQHWDMGGP-UHFFFAOYSA-N

Smiles

CNC(=C[N+](=O)[O-])NCCSCc1csc(CN(C)C)n1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular > 225mg/kg (225mg/kg) BEHAVIORAL: TETANY

BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
dog LD50 intravenous > 75mg/kg (75mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: TREMOR		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
dog LD50 oral > 800mg/kg (800mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
monkey LD50 intravenous > 200mg/kg (200mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
monkey LD50 oral > 1200mg/kg (1200mg/kg)   Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
mouse LD50 intravenous 232mg/kg (232mg/kg)   Drugs in Japan Vol. -, Pg. 920, 1995.
mouse LD50 oral 1630mg/kg (1630mg/kg)   Drugs in Japan Vol. -, Pg. 920, 1995.
mouse LD50 subcutaneous 1082mg/kg (1082mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: COMA		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
rat LD50 intravenous 301mg/kg (301mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: COMA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.
rat LD50 oral 1653mg/kg (1653mg/kg)   Drugs in Japan Vol. -, Pg. 920, 1995.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: COMA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"		 Fundamental and Applied Toxicology. Vol. 13, Pg. 778, 1989.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 130-132 deg C   EXP
log P (octanol-water) -0.430 (none)   EST
Atmospheric OH Rate Constant 2.44E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.