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Substance Name: Procyclidine [INN:BAN]
RN: 77-37-2
UNII: C6QE1Q1TKR
InChIKey: WYDUSKDSKCASEF-UHFFFAOYSA-N

Note

  • A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.

Molecular Formula

  • C19-H29-N-O

Molecular Weight

  • 287.444
 

Classification Codes

  • Anti-Dyskinesia Agents
  • Antiparkinson Agents
  • Central Nervous System Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Muscarinic Antagonists
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Procyclidine
  • Procyclidine [INN:BAN]

MeSH Heading

  • Procyclidine

Synonyms

  • 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol
  • 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
  • 5-20-01-00250 (Beilstein Handbook Reference)
  • Arpicolin
  • BRN 0088563
  • EINECS 201-023-0
  • Elorine
  • HSDB 7678
  • Kemadrine
  • Lergine
  • Metanin
  • NSC 169103
  • Osnervan
  • Prociclidina
  • Prociclidina [INN-Spanish]
  • Procidlidina
  • Procyclidine
  • Procyclidinum
  • Procyclidinum [INN-Latin]
  • Procyklidin
  • Spamol
  • Triciclidina
  • Tricoloid
  • Tricyclamol
  • UNII-C6QE1Q1TKR
  • Vagosin

Systematic Names

  • 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-
  • Procyclidine

Registry Numbers

CAS Registry Number

  • 77-37-2

FDA UNII

  • C6QE1Q1TKR

Other Registry Numbers

  • 107661-03-0
  • 56172-67-9

System Generated Number

  • 0000077372

Structure Descriptors

InChI

InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2

InChIKey

WYDUSKDSKCASEF-UHFFFAOYSA-N

Smiles

OC(CCN1CCCC1)(C2CCCCC2)c3ccccc3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 131mg/kg (131mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 291, 1972.
mouse LD50 intravenous 60mg/kg (60mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 291, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 86 deg C   EXP
log P (octanol-water) 4.780 (none)   EST
Atmospheric OH Rate Constant 1.19E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.