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Substance Name: Procyclidine [INN:BAN]
RN: 77-37-2
UNII: C6QE1Q1TKR
InChIKey: WYDUSKDSKCASEF-UHFFFAOYSA-N
Note
- A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Molecular Formula
- C19-H29-N-O
Molecular Weight
- 287.444
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Anti-Dyskinesia Agents
- Antiparkinson Agents
- Central Nervous System Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Muscarinic Antagonists
- Neurotransmitter Agents
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Links to Resources
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Names and Synonyms
Name of Substance
- Procyclidine
- Procyclidine [INN:BAN]
MeSH Heading
- Procyclidine
Synonyms
- 1-Cyclohexyl-1-phenyl-3-(1-pyrrolidinyl)-1-propanol
- 1-Cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol
- 5-20-01-00250 (Beilstein Handbook Reference)
- Arpicolin
- BRN 0088563
- EINECS 201-023-0
- Elorine
- HSDB 7678
- Kemadrine
- Lergine
- Metanin
- NSC 169103
- Osnervan
- Prociclidina
- Prociclidina [INN-Spanish]
- Procidlidina
- Procyclidine
- Procyclidinum
- Procyclidinum [INN-Latin]
- Procyklidin
- Spamol
- Triciclidina
- Tricoloid
- Tricyclamol
- UNII-C6QE1Q1TKR
- Vagosin
Systematic Names
- 1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-
- Procyclidine
Registry Numbers
CAS Registry Number
- 77-37-2
FDA UNII
- C6QE1Q1TKR
Other Registry Numbers
- 107661-03-0
- 56172-67-9
System Generated Number
- 0000077372
Structure Descriptors
InChI
InChI=1S/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2InChIKey
WYDUSKDSKCASEF-UHFFFAOYSA-NSmiles
OC(CCN1CCCC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 131mg/kg (131mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 291, 1972. | |
mouse | LD50 | intravenous | 60mg/kg (60mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 291, 1972. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 86 | deg C | EXP | |
log P (octanol-water) | 4.780 | (none) | EST | |
Atmospheric OH Rate Constant | 1.19E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.