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Substance Name: Methsuximide [USP]
RN: 77-41-8
UNII: 0G76K8X6C0
InChIKey: AJXPJJZHWIXJCJ-UHFFFAOYSA-N

Note

  • Anticonvulsant effective in petit mal & psychomotor epilepsy; has a number of unpleasant & toxic side effects.

Molecular Formula

  • C12-H13-N-O2

Molecular Weight

  • 203.24
 

Classification Codes

  • Anticonvulsant
  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Mesuximide [INN]
  • Methsuximide
  • Methsuximide [USP]

Synonyms

  • (+-)-N,2-Dimethyl-2-phenylsuccinimide
  • (RS)-1,3-Dimethyl-3-phenyl-2,5-pyrrolidindion
  • 1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine
  • 1,3-Dimethyl-3-phenyl-pyrrolidin-2,5-dione
  • 1,3-Dimethyl-3-phenylsuccinimide
  • 2,5-Pyrrolidinedione, 1,3-dimethyl-3-phenyl-
  • 2,5-Pyrrolidinedione,1,3-dimethyl-3-phenyl-, (+-)-
  • 5-21-11-00209 (Beilstein Handbook Reference)
  • alpha-Methyl-alpha-phenyl N-methyl succinimide
  • alpha-Methylphensuximide
  • BRN 0168315
  • Celontin
  • EINECS 201-026-7
  • HSDB 3124
  • Mesuximida
  • Mesuximida [INN-Spanish]
  • Mesuximide
  • Mesuximidum
  • Mesuximidum [INN-Latin]
  • Methsuximid
  • Methsuximide
  • Metosuccimmide
  • Metosuccimmide [DCIT]
  • Metsuccimide
  • N,2-Dimethyl-2-phenylsuccinimide
  • N-Methyl-alpha-methyl-alpha-phenylsuccinimide
  • Petinutin
  • PM 396
  • Succinimide, N,2-dimethyl-2-phenyl-
  • UNII-0G76K8X6C0

Systematic Names

  • 2,5-Pyrrolidinedione,1,3-dimethyl-3-phenyl-
  • Mesuximide
  • Succinimide, N,2-dimethyl-2-phenyl-

Registry Numbers

CAS Registry Number

  • 77-41-8

FDA UNII

  • 0G76K8X6C0

System Generated Number

  • 0000077418

Structure Descriptors

InChI

1S/C12H13NO2/c1-12(9-6-4-3-5-7-9)8-10(14)13(2)11(12)15/h3-7H,8H2,1-2H3

InChIKey

AJXPJJZHWIXJCJ-UHFFFAOYSA-N

Smiles

c1([C@@]2(C(N(C)C(C2)=O)=O)C)ccccc1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 900mg/kg (900mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 6, Pg. 740, 1954.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 52.5 deg C   EXP
log P (octanol-water) 1.450 (none)   EST
Water Solubility 5190 mg/L 25 EST
Vapor Pressure 4.77E-06 mm Hg 25 EST
Henry's Law Constant 5.96E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.21E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.