Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Acedapsone [USAN:INN:BAN]
RN: 77-46-3
UNII: 0GZ72U84TN
InChIKey: AMTPYFGPPVFBBI-UHFFFAOYSA-N

Note

  • Acetylated sulfone that is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent.

Molecular Formula

  • C16-H16-N2-O4-S

Molecular Weight

  • 332.3784
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterial (Leprostatic)
  • Antimalarial
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Leprostatic Agents
  • Tumor Data
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Acedapsone
  • Acedapsone [USAN:INN:BAN]

MeSH Heading

  • Acedapsone

Synonyms

  • 1399 F
  • 4',4'''-Sulfonylbis(acetanilide)
  • 4',4'''-Sulfonylbis(acetanilidec)
  • 4,4'-Bis(acetylamino)diphenyl sulfone
  • 4,4'-Diacetamidodiphenyl sulfone
  • 4,4'-Diacetylaminodiphenyl sulfone
  • 4,4'-Diacetyldiaminodiphenyl sulfone
  • 4-13-00-01361 (Beilstein Handbook Reference)
  • Acedafsonum
  • Acedafsonum [Latin]
  • Acedapsona
  • Acedapsona [INN-Spanish]
  • Acedapsona [Spanish]
  • Acedapsone
  • Acedapsonum
  • Acedapsonum [INN-Latin]
  • Acetamide. N,N'-(sulfonyldi-4,1-phenylene)bis-
  • Acetamin
  • Acetanilide, 4',4'''-sulfonyldi-
  • AI3-32581
  • Atilon
  • BA 2650
  • Bis(4-acetamidophenyl) sulfone
  • Bis(4-acetamidophenyl)sulfone
  • Bis(p-acetamidophenyl) sulfone
  • BRN 2164071
  • Camilan
  • CCRIS 5694
  • CI 556
  • CN 1883
  • CN-1883
  • DADDS
  • Di-(p-acetylaminophenyl)sulfone
  • Diacetyldapsone
  • EINECS 201-028-8
  • Hansolar
  • N,N'-(Sulfonyldi-4,1-phenylene)bisacetamide
  • N,N'-Diacetyl-4,4'-diaminodiphenyl sulfone
  • N,N'-Diacetyl-4,4'-diaminophenyl sulfone
  • N,N'-Diacetyldapsone
  • NSC 218125
  • NSC 655049
  • p,p'-Sulfonylbisacetanilide
  • PAM-MR-1165
  • Rodilone
  • Sulfadiamine
  • Sulfodiamin
  • Sulfodiamine
  • Sulfone, bis(p-acetamidophenyl)
  • UNII-0GZ72U84TN

Systematic Names

  • Acedapsone
  • Acetamide, N,N'-(sulfonyldi-4,1-phenylene)bis-
  • Acetanilide, 4',4'''-sulfonylbis-
  • N,N'-Diacetyl-4,4'-diaminodiphenylsulfone

Registry Numbers

CAS Registry Number

  • 77-46-3

FDA UNII

  • 0GZ72U84TN

System Generated Number

  • 0000077463

Structure Descriptors

InChI

1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)

InChIKey

AMTPYFGPPVFBBI-UHFFFAOYSA-N

Smiles

S(=O)(=O)(c1ccc(cc1)NC(=O)C)c1ccc(cc1)NC(=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 4gm/kg (4000mg/kg)   Journal of the American Chemical Society. Vol. 61, Pg. 617, 1939.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 290 deg C   EXP
log P (octanol-water) 0.820 (none)   EST
Atmospheric OH Rate Constant 5.51E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.