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Substance Name: Ethosuximide [USAN:USP:INN:BAN:JAN]
RN: 77-67-8
UNII: 5SEH9X1D1D
InChIKey: HAPOVYFOVVWLRS-UHFFFAOYSA-N

Note

  • An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.

Molecular Formula

  • C7-H11-N-O2

Molecular Weight

  • 141.169
 

Classification Codes

  • Anticonvulsant
  • Anticonvulsants
  • Central Nervous System Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Ethosuximide
  • Ethosuximide [USAN:USP:INN:BAN:JAN]

MeSH Heading

  • Ethosuximide

Synonyms

  • (+-)-2-Ethyl-2-methylsuccinimide
  • 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-
  • 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-, (+-)-
  • 2-Ethyl-2-methylsuccinimide
  • 2-Methyl-2-ethylsuccinimide
  • 3-Ethyl-3-methylpyrrolidine-2,5-dione
  • 3-Ethyl-3-methylsuccinimide
  • 3-Methyl-3-ethylpyrrolidine-2,5-dione
  • 3-Methyl-3-ethylsuccinimide
  • 5-21-09-00595 (Beilstein Handbook Reference)
  • Aethosuccimidum
  • Aethosuximide
  • Aethosuximide [German]
  • alpha-Ethyl-alpha-methylsuccinimide
  • alpha-Methyl-alpha-ethylsuccinimide
  • Asamid
  • Atysmal
  • BRN 0117054
  • C.I. 366
  • Capitus
  • CI 366
  • CI-366
  • CN-10,395
  • EINECS 201-048-7
  • Emeside
  • Epileo Petit MAL
  • Ethosuccimide
  • Ethosuccinimide
  • Ethosuxide
  • Ethosuximide
  • Ethosuximidum
  • Ethosuximidum [INN-Latin]
  • Ethymal
  • Etomal
  • Etosuccimide
  • Etosuccimide [DCIT]
  • Etosuximid
  • Etosuximida
  • Etosuximida [INN-Spanish]
  • Etosuximide
  • gamma-Methyl-gamma-ethyl-succinimide
  • H 940
  • H-490
  • HSDB 1119
  • Mesentol
  • N-Ethyl methylsuccinimide
  • NSC 64013
  • Pemal
  • Pemalin
  • Pentinimid
  • Peptinimid
  • Petinimid
  • Petnidan
  • Piknolepsin
  • PM 671
  • PM-671
  • Pyknolepsinum
  • Ronton
  • Simatin
  • Simatin(E)
  • Succimal
  • Succimitin
  • Succinimide, 2-ethyl-2-methyl-
  • Suxilep
  • Suximal
  • Suxin
  • Suxinutin
  • Thetamid
  • Thilopemal
  • UNII-5SEH9X1D1D
  • Zaraondan
  • Zarodan
  • Zarondan
  • Zarondan-saft
  • Zarontin
  • Zartalin

Systematic Names

  • 2,5-Pyrrolidinedione, 3-ethyl-3-methyl-
  • Ethosuximide
  • Succinimide, 2-ethyl-2-methyl-

Registry Numbers

CAS Registry Number

  • 77-67-8

FDA UNII

  • 5SEH9X1D1D

System Generated Number

  • 0000077678

Structure Descriptors

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChIKey

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Smiles

C1([C@@](CC(=O)N1)(CC)C)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1325mg/kg (1325mg/kg)   United States Patent Document. Vol. #4188398,
mouse LD50 intravenous 780mg/kg (780mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Neuropharmacology. Vol. 24, Pg. 427, 1985.
mouse LD50 oral 1530mg/kg (1530mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Epilepsia Vol. 4(4), Pg. 66, 1963.
mouse LD50 subcutaneous 1810mg/kg (1810mg/kg)   Drugs in Japan Vol. 6, Pg. 117, 1982.
rat LD50 oral 1820mg/kg (1820mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 64.5 deg C   EXP
log P (octanol-water) 0.38 (none)   EXP
Water Solubility 3.92E+04 mg/L 25 EST
Vapor Pressure 5.43E-07 mm Hg 25 EST
Henry's Law Constant 5.93E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.16E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.