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Substance Name: Tromethamine [USAN:USP]
RN: 77-86-1
UNII: 023C2WHX2V
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N

Note

  • An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424).

Molecular Formula

  • C4-H11-N-O3

Molecular Weight

  • 121.135
 

Classification Codes

  • Buffers
  • Drug / Therapeutic Agent
  • Excipients
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles

Names and Synonyms

Name of Substance

  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
  • Tham
  • Tris(hydroxymethyly)amino methane
  • Trometamol [INN]
  • Tromethamine
  • Tromethamine [USAN:USP]

MeSH Heading

  • Tromethamine

Synonyms

  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
  • 2-(Hydroxymethyl)-2-amino-1,3-propanediol
  • 2-Amino-2-(hydroxymethyl)-1,3-propanediol
  • 2-Amino-2-methylol-1,3-propanediol
  • Addex-tham
  • AI3-03948
  • Aminotrimethylolmethane
  • Aminotris(hydroxymethyl)methane
  • Apiroserum Tham
  • Caswell No. 036
  • EC 201-064-4
  • EINECS 201-064-4
  • EPA Pesticide Chemical Code 083901
  • HSDB 3408
  • Methanamine, 1,1,1-tris(hydroxymethyl)-
  • Methylamine, 1,1,1-tris(hydroxymethyl)-
  • NSC 6365
  • Pehanorm
  • Talatrol
  • Tham
  • THAM-E
  • Trimethylolaminomethane
  • Tris
  • Tris (buffering agent)
  • Tris buffer
  • Tris(hydroxymethyl)aminomethane
  • Tris(hydroxymethyl)methanamine
  • Tris(hydroxymethyl)methylamine
  • Tris, free base
  • Tris-base
  • Tris-hydroxymethyl-aminomethan
  • Tris-hydroxymethyl-aminomethan [German]
  • Tris-hydroxymethylaminomethane
  • Tris-steril
  • Trisamine
  • Trisaminol
  • Trispuffer
  • Trizma
  • Trometamol
  • Trometamolum
  • Trometamolum [INN-Latin]
  • Tromethamine
  • Tromethamolum
  • Tromethane
  • Tutofusin tris
  • UNII-023C2WHX2V

Systematic Names

  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
  • Trometamol

Superlist Names

  • 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
  • 2-Amino-2-hydroxymethyl-1,3-propanediol solution
  • Tris(hydroxymethyl)aminomethane

Registry Numbers

CAS Registry Number

  • 77-86-1

FDA UNII

  • 023C2WHX2V

Other Registry Numbers

  • 108195-86-4
  • 1158650-64-6
  • 119320-15-9
  • 25149-07-9
  • 68755-45-3
  • 83147-39-1
  • 857365-23-2

System Generated Number

  • 0000077861

Structure Descriptors

InChI

InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2

InChIKey

LENZDBCJOHFCAS-UHFFFAOYSA-N

Smiles

NC(CO)(CO)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 1210mg/kg (1210mg/kg)   Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966.
rabbit LDLo oral 1gm/kg (1000mg/kg) BEHAVIORAL: COMA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS		 Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940.
rat LD50 intravenous 1800mg/kg (1800mg/kg)   Drugs in Japan Vol. -, Pg. 419, 1990.
rat LD50 oral 5900mg/kg (5900mg/kg)   Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 171.5 deg C   EXP
pKa Dissociation Constant 8.069 (none)   EXP
log P (octanol-water) -1.560 (none)   EST
Water Solubility 5.50E+05 mg/L 25 EXP
Vapor Pressure 2.20E-05 mm Hg 25 EST
Henry's Law Constant 8.67E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 3.35E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.