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Substance Name: Tromethamine [USAN:USP]
RN: 77-86-1
UNII: 023C2WHX2V
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
Note
- An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424).
Molecular Formula
- C4-H11-N-O3
Molecular Weight
- 121.135
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Names and Synonyms
Name of Substance
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
- Tham
- Tris(hydroxymethyly)amino methane
- Trometamol [INN]
- Tromethamine
- Tromethamine [USAN:USP]
MeSH Heading
- Tromethamine
Synonyms
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
- 2-(Hydroxymethyl)-2-amino-1,3-propanediol
- 2-Amino-2-(hydroxymethyl)-1,3-propanediol
- 2-Amino-2-methylol-1,3-propanediol
- Addex-tham
- AI3-03948
- Aminotrimethylolmethane
- Aminotris(hydroxymethyl)methane
- Apiroserum Tham
- Caswell No. 036
- EC 201-064-4
- EINECS 201-064-4
- EPA Pesticide Chemical Code 083901
- HSDB 3408
- Methanamine, 1,1,1-tris(hydroxymethyl)-
- Methylamine, 1,1,1-tris(hydroxymethyl)-
- NSC 6365
- Pehanorm
- Talatrol
- Tham
- THAM-E
- Trimethylolaminomethane
- Tris
- Tris (buffering agent)
- Tris buffer
- Tris(hydroxymethyl)aminomethane
- Tris(hydroxymethyl)methanamine
- Tris(hydroxymethyl)methylamine
- Tris, free base
- Tris-base
- Tris-hydroxymethyl-aminomethan
- Tris-hydroxymethyl-aminomethan [German]
- Tris-hydroxymethylaminomethane
- Tris-steril
- Trisamine
- Trisaminol
- Trispuffer
- Trizma
- Trometamol
- Trometamolum
- Trometamolum [INN-Latin]
- Tromethamine
- Tromethamolum
- Tromethane
- Tutofusin tris
- UNII-023C2WHX2V
Systematic Names
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
- Trometamol
Superlist Names
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-
- 2-Amino-2-hydroxymethyl-1,3-propanediol solution
- Tris(hydroxymethyl)aminomethane
Registry Numbers
CAS Registry Number
- 77-86-1
FDA UNII
- 023C2WHX2V
Other Registry Numbers
- 108195-86-4
- 1158650-64-6
- 119320-15-9
- 25149-07-9
- 68755-45-3
- 83147-39-1
- 857365-23-2
System Generated Number
- 0000077861
Structure Descriptors
InChI
InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2InChIKey
LENZDBCJOHFCAS-UHFFFAOYSA-NSmiles
NC(CO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 1210mg/kg (1210mg/kg) | Acta Biologica et Medica Germanica. Vol. 17, Pg. 217, 1966. | |
rabbit | LDLo | oral | 1gm/kg (1000mg/kg) | BEHAVIORAL: COMA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS | Journal of Industrial Hygiene and Toxicology. Vol. 22, Pg. 315, 1940. |
rat | LD50 | intravenous | 1800mg/kg (1800mg/kg) | Drugs in Japan Vol. -, Pg. 419, 1990. | |
rat | LD50 | oral | 5900mg/kg (5900mg/kg) | Bollettino Chimico Farmaceutico. Vol. 110, Pg. 653, 1971. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 171.5 | deg C | EXP | |
pKa Dissociation Constant | 8.069 | (none) | EXP | |
log P (octanol-water) | -1.560 | (none) | EST | |
Water Solubility | 5.50E+05 | mg/L | 25 | EXP |
Vapor Pressure | 2.20E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 8.67E-13 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 3.35E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.