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Substance Name: Citric acid, anhydrous [USP:JAN]
RN: 77-92-9
UNII: XF417D3PSL
InChIKey: KRKNYBCHXYNGOX-UHFFFAOYSA-N

Note

  • A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.

Molecular Formula

  • C6-H8-O7

Molecular Weight

  • 192.122
 

Classification Codes

  • Agricultural Chemical
  • Anticoagulants
  • Chelating Agents
  • Drug / Therapeutic Agent
  • Fungicide, Bactericide, Wood Preservative
  • Hematologic Agents
  • Skin / Eye Irritant

Names and Synonyms

Name of Substance

  • Citric acid
  • Citric acid, anhydrous [USP:JAN]

MeSH Heading

  • Citric acid

Synonyms

  • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-
  • 2-Hydroxy-1,2,3-propanetricarboxylic acid
  • 2-Hydroxypropanetricarboxylic acid
  • 2-Hydroxytricarballylic acid
  • 3-Carboxy-3-hydroxypentane-1,5-dioic acid
  • 4-03-00-01272 (Beilstein Handbook Reference)
  • Aciletten
  • AI3-06286
  • Anhydrous citric acid
  • BRN 0782061
  • Caswell No. 221C
  • CCRIS 3292
  • Chemfill
  • Citretten
  • Citric acid
  • Citric acid, anhydrous
  • Citro
  • EC 201-069-1
  • EINECS 201-069-1
  • EPA Pesticide Chemical Code 021801
  • F 0001 (polycarboxylic acid)
  • FEMA No. 2306
  • FEMA Number 2306
  • HSDB 911
  • Hydrocerol A
  • Kyselina 2-hydroxy-1,2,3-propantrikarbonova
  • Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]
  • Kyselina citronova
  • Kyselina citronova [Czech]
  • NSC 30279
  • NSC 626579
  • UNII-XF417D3PSL

Systematic Names

  • 1,2,3-Propanetricarboxylic acid, 2-hydroxy-
  • Citric acid

Superlist Names

  • 2-Hydroxy-1,2,3-propanetricarboxylic acid
  • Citric acid

Mixture Names

  • K-Lyte
  • K-Lyte DS
  • K-Lyte/Cl

Registry Numbers

CAS Registry Number

  • 77-92-9

FDA UNII

  • XF417D3PSL

Other Registry Numbers

  • 1192555-95-5
  • 12262-73-6
  • 136108-93-5
  • 2023788-69-2
  • 245654-34-6
  • 43136-35-2
  • 623158-96-3
  • 856568-15-5
  • 878903-72-1
  • 890704-54-8
  • 896506-46-0
  • 906507-37-7

System Generated Number

  • 0000077929

Structure Descriptors

InChI

1S/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

InChIKey

KRKNYBCHXYNGOX-UHFFFAOYSA-N

Smiles

C(CC(O)=O)(CC(O)=O)(C(O)=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 903mg/kg (903mg/kg)   Toxicology. Vol. 62, Pg. 203, 1990.
mouse LD50 intravenous 42mg/kg (42mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: CYANOSIS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
mouse LD50 oral 5040mg/kg (5040mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

MUSCULOSKELETAL: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
mouse LD50 subcutaneous 2700mg/kg (2700mg/kg) MUSCULOSKELETAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.
rabbit LD50 intravenous 330mg/kg (330mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of Pharmacology and Experimental Therapeutics. Vol. 94, Pg. 65, 1948.
rabbit LDLo oral 7gm/kg (7000mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Industrial and Engineering Chemistry. Vol. 15, Pg. 628, 1923.
rat LD50 intraperitoneal 290mg/kg (290mg/kg)   Toksikologicheskii Vestnik. Vol. (5), Pg. 9, 1994.
rat LD50 oral 3gm/kg (3000mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 43, Pg. 561, 1992.
rat LD50 subcutaneous 5500mg/kg (5500mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

MUSCULOSKELETAL: OTHER CHANGES
Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. Vol. 30, Pg. 25, 1971.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 153 deg C   EXP
pKa Dissociation Constant 2.79 (none)   EXP
log P (octanol-water) -1.64E+00 (none)   EXP
Water Solubility 5.92E+05 mg/L 20 EXP
Vapor Pressure 3.70E-09 mm Hg 25 EST
Henry's Law Constant 8.33E-18 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 7.02E-12 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.