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Substance Name: Dizocilpine maleate [USAN]
RN: 77086-22-7
UNII: 6LR8C1B66Q
InChIKey: QLTXKCWMEZIHBJ-PJGJYSAQSA-N

Note

  • A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.

Molecular Formula

  • C16-H15-N.C4-H4-O4

Molecular Weight

  • 337.3731
 

Classification Codes

  • Central Nervous System Agents
  • Excitatory Amino Acid Agents
  • Excitatory Amino Acid Antagonists
  • Neuroprotective
  • Neuroprotective Agents
  • Neurotransmitter Agents
  • Protective Agents
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Names and Synonyms

Name of Substance

  • Dizocilpine maleate
  • Dizocilpine maleate [USAN]

MeSH Heading

  • Dizocilpine maleate

Synonyms

  • (+)-10,11-Dihydro-5-methyl-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (1:1)
  • 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (+)-, (Z)-2-butenedioate (1:1)
  • Dizocilpine hydrogen maleate
  • Dizocilpine maleate
  • EINECS 278-614-5
  • MK 801
  • MK-801
  • UNII-6LR8C1B66Q

Systematic Names

  • (+)-10,11-Dihydro-5-methyl-5H-dibenzo(a,d)cyclohepten-5,10-diyldiammonium maleate
  • 5H-Dibenzo(a,d)cyclohepten-5,10-imine, 10,11-dihydro-5-methyl-, (+)-, (Z)-2-butenedioate (1:1)

Registry Numbers

CAS Registry Number

  • 77086-22-7

FDA UNII

  • 6LR8C1B66Q

Related Registry Number

  • 77086-21-6 (parent)

System Generated Number

  • 0077086227

Molecular Formulas

Molecular Formula

  • C16-H15-N.C4-H4-O4

Molecular Formula Fragments

  • C16-H15-N
  • C4-H4-O4
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1

InChIKey

QLTXKCWMEZIHBJ-PJGJYSAQSA-N

Smiles

C[C@]12N[C@H](Cc3ccccc13)c4ccccc24.OC(=O)\C=C/C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 30mg/kg (30mg/kg)   United States Patent Document. Vol. #5273989,