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Substance Name: Croconazole Hydrochloride [JAN]
RN: 77174-66-4
UNII: I0WFH323HZ
InChIKey: LWJUIYYIILPRRI-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H15-Cl-N2-O.Cl-H

Molecular Weight

  • 347.2434
 
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Names and Synonyms

Name of Substance

  • Croconazole Hydrochloride [JAN]

Synonyms

  • 1-(1-(2-((3-Chlorobenzyl)oxy)phenyl)vinyl)-1H-imidazole hydrochloride
  • 1-(1-(2-((3-Chlorophenyl)methoxy)phenyl)ethenyl)-1H-imidazole hydrochloride
  • 1-(1-(2-((3-Clorobenzil)oxi)fenil)vinil)-1H-imidazol monoclorhidrato
  • 1-(1-(2-((3-Clorobenzil)oxi)fenil)vinil)-1H-imidazol monoclorhidrato [Spanish]
  • 1-(1-(2-((3-Clorofenil)metoxi)fenil)etenil)-1H-imidazol monoclorhidrato
  • 1-(1-(2-((3-Clorofenil)metoxi)fenil)etenil)-1H-imidazol monoclorhidrato [Spanish]
  • 1-(1-O-(m-(Chlorobenzyloxy)phenyl)vinyl)-1H-imidazole hydrochloride
  • 710674-S
  • Croconazol clorhidrato
  • Croconazol clorhidrato [Spanish]
  • Croconazole hydrochloride
  • Pilzcin
  • UNII-I0WFH323HZ

Systematic Names

  • 1H-Imidazole, 1-(1-(2-((3-chlorobenzyl)oxy)phenyl)vinyl)-, monohydrochloride
  • 1H-Imidazole, 1-(1-(2-((3-chlorophenyl)methoxy)phenyl)ethenyl)-, monohydrochloride (9CI)

Registry Numbers

CAS Registry Number

  • 77174-66-4

FDA UNII

  • I0WFH323HZ

Other Registry Number

  • 99465-73-3

Related Registry Number

  • 77175-51-0 (Parent)

System Generated Number

  • 0077174664

Molecular Formulas

Molecular Formula

  • C18-H15-Cl-N2-O.Cl-H

Molecular Formula Fragments

  • C18-H15-Cl-N2-O
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H15ClN2O.ClH/c1-14(21-10-9-20-13-21)17-7-2-3-8-18(17)22-12-15-5-4-6-16(19)11-15;/h2-11,13H,1,12H2;1H

InChIKey

LWJUIYYIILPRRI-UHFFFAOYSA-N

Smiles

C=C(c1ccccc1OCc2cccc(c2)Cl)n3ccnc3.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 94mg/kg (94mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
mouse LD50 oral 1150mg/kg (1150mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
mouse LD50 subcutaneous 1gm/kg (1000mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
rabbit LD skin > 320mg/kg (320mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4847, 1984.
rabbit LDLo subcutaneous 1715mg/kg (1715mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4821, 1984.
rat LD50 intraperitoneal 204mg/kg (204mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
rat LD50 oral 2gm/kg (2000mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
rat LD50 skin > 600mg/kg (600mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.
rat LD50 subcutaneous 4700mg/kg (4700mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 18, Pg. 4811, 1984.