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Substance Name: Maytansine, O(sup 3)-acetyl-O(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-22-demethyl-
RN: 77353-67-4
InChIKey: IDPXHMRTHALESG-AXWXSLIPSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C29-H37-Cl-N2-O9

Molecular Weight

  • 593.0693
 
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Names and Synonyms

Synonym

  • Antibiotic C 15003PND-1

Systematic Name

  • Maytansine, O(sup 3)-acetyl-O(sup 3)-de(2-(acetylmethylamino)-1-oxopropyl)-22-demethyl-

Registry Numbers

CAS Registry Number

  • 77353-67-4

System Generated Number

  • 0077353674

Structure Descriptors

InChI

1S/C29H37ClN2O9/c1-15-8-7-9-22(38-6)29(36)14-21(40-27(35)32-29)16(2)26-28(4,41-26)23(39-17(3)33)13-24(34)31-19-11-18(10-15)12-20(37-5)25(19)30/h7-9,11-12,16,21-23,26,36H,10,13-14H2,1-6H3,(H,31,34)(H,32,35)/b9-7+,15-8+/t16-,21+,22+,23+,26?,28+,29+/m1/s1

InChIKey

IDPXHMRTHALESG-AXWXSLIPSA-N

Smiles

C[C@@H]1[C@@H]2C[C@]([C@H](/C=C/C=C(/Cc3cc(c(c(c3)OC)Cl)NC(=O)C[C@@H]([C@]4(C1O4)C)OC(=O)C)\C)OC)(NC(=O)O2)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 1gm/kg (1000mg/kg)   Japanese Kokai Tokyo Koho Patents. Vol. #80-118490,
mouse LDLo intraperitoneal 2500ug/kg (2.5mg/kg)   European Patent Application. Vol. #25898,