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Substance Name: Milbemycin D
RN: 77855-81-3
UNII: 04S0E2XJQI
InChIKey: BWCRYQGQPDBOAU-WZBVPYLGSA-N

Classification Code

  • Natural Product

Molecular Formula

  • C33-H48-O7

Molecular Weight

  • 556.735
 
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Names and Synonyms

Name of Substance

  • Milbemycin D

Synonyms

  • (6R,25)-5-O-Demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)milbemycin B
  • Antibiotic B 41D
  • B 41D
  • BRN 4282549
  • Milbemycin D
  • UNII-04S0E2XJQI

Systematic Name

  • Milbemycin B, 5-O-demethyl-28-deoxy-6,28-epoxy-25-(1-methylethyl)-, (6R,25R)-

Registry Numbers

CAS Registry Number

  • 77855-81-3

FDA UNII

  • 04S0E2XJQI

System Generated Number

  • 0077855813

Structure Descriptors

InChI

1S/C33H48O7/c1-19(2)29-22(5)12-13-32(40-29)17-26-16-25(39-32)11-10-21(4)14-20(3)8-7-9-24-18-37-30-28(34)23(6)15-27(31(35)38-26)33(24,30)36/h7-10,15,19-20,22,25-30,34,36H,11-14,16-18H2,1-6H3/b8-7+,21-10+,24-9+/t20-,22-,25+,26-,27-,28+,29+,30+,32+,33+/m0/s1

InChIKey

BWCRYQGQPDBOAU-WZBVPYLGSA-N

Smiles

C1O[C@H]2[C@@]3(C1=CC=C[C@H](C)CC(=CC[C@H]1O[C@@]4(C[C@H](C1)OC(=O)[C@@H]3C=C([C@H]2O)C)O[C@H](C(C)C)[C@@H](C)CC4)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 668mg/kg (668mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
mouse LD50 oral 1610mg/kg (1610mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) BLOOD: HEMORRHAGE

BLOOD: CHANGES IN SPLEEN
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat LD50 intraperitoneal > 2gm/kg (2000mg/kg)   Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat LD50 oral 2467mg/kg (2467mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BLOOD: HEMORRHAGE

BLOOD: CHANGES IN SPLEEN
Sankyo Kenkyusho Nempo. Annual Report of Sankyo Research Laboratories. Vol. 35, Pg. 71, 1983.