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Substance Name: Doxazosin mesylate [USAN:USP]
RN: 77883-43-3
UNII: 86P6PQK0MU
InChIKey: VJECBOKJABCYMF-UHFFFAOYSA-N

Note

  • A selective alpha-1-adrenergic blocker that lowers serum CHOLESTEROL. It is also effective in the treatment of HYPERTENSION.

Molecular Formula

  • C23-H25-N5-O5.C-H4-O3-S

Molecular Weight

  • 547.5861
 

Classification Codes

  • Antihypertensive
  • Drug / Therapeutic Agent
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Doxazosin mesylate
  • Doxazosin mesylate [USAN:USP]

MeSH Heading

  • Doxazosin

Synonyms

  • 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine monomethanesulfonate
  • Alfadil
  • Benur
  • Cardenalin
  • Cardoral
  • Cardoxan
  • Cardular
  • Cardular PP
  • Cardular Uro
  • Cardura
  • Cardura XL
  • Carduran
  • Dedralen
  • Diblocin
  • Diblocin PP
  • Diblocin Uro
  • Doksura
  • Dosin
  • Doxaben
  • Doxazocine
  • Doxazomerck
  • Doxazosin
  • Doxazosin AZU
  • Doxazosin mesilate
  • Doxazosin mesylate
  • Doxolbran
  • Duracin
  • HSDB 7082
  • Kaltensif
  • Normathen
  • Progandol
  • Prostadilat
  • Supressin
  • Tensiobas
  • Tonocardin
  • UK 33,274-27
  • UK-33,274-27
  • UNII-86P6PQK0MU

Systematic Name

  • Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, monomethanesulfonate

Registry Numbers

CAS Registry Number

  • 77883-43-3

FDA UNII

  • 86P6PQK0MU

Related Registry Number

  • 74191-85-8 (Parent)

System Generated Number

  • 0077883433

Molecular Formulas

Molecular Formula

  • C23-H25-N5-O5.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C23-H25-N5-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)

InChIKey

VJECBOKJABCYMF-UHFFFAOYSA-N

Smiles

COc1cc2c(cc1OC)nc(nc2N)N3CCN(CC3)C(=O)C4COc5ccccc5O4.CS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral > 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
mouse LD50 intraperitoneal 247mg/kg (247mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
mouse LD50 oral 2935mg/kg (2935mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
mouse LD50 subcutaneous 4087mg/kg (4087mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
rat LD50 intraperitoneal 380mg/kg (380mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
rat LD50 oral > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg)   Drugs in Japan Vol. -, Pg. 712, 1990.