Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Tri-o-cresyl phosphate
RN: 78-30-8
UNII: X8II18JD0A
InChIKey: YSMRWXYRXBRSND-UHFFFAOYSA-N

Note

  • See also related IMOL S-140.

Molecular Formula

  • C21-H21-O4-P

Molecular Weight

  • 368.3669
 

Classification Codes

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data
  • Plasticizers
  • Reproductive Effect

Superlist Classification Codes

  • TWA 0.1 mg/m3
  • TWA 0.1 mg/m3; skin; Not classifiable as a human carcinogen; BEI
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Tri-o-cresyl phosphate

Synonyms

  • 4-06-00-01979 (Beilstein Handbook Reference)
  • AI3-00520
  • BRN 1892885
  • CCRIS 6421
  • EINECS 201-103-5
  • HSDB 4084
  • NSC 438
  • o-Cresyl phosphate
  • o-Tolyl phosphate
  • o-Trikresylphosphate
  • o-Trikresylphosphate [German]
  • Phosflex 179C
  • Phosphoric acid, tri(2-tolyl)ester
  • Phosphoric acid, tri-o-cresyl ester
  • Phosphoric acid, tri-o-tolyl ester
  • Phosphoric acid, tris(2-methylphenyl) ester
  • TOCP
  • TOTP
  • Tri 2-methylphenyl phosphate
  • Tri-2-methylphenyl phosphate
  • Tri-2-tolyl phosphate
  • Tri-o-cresyl phosphate
  • Tri-o-tolyl phosphate
  • Triorthocresyl phosphate
  • Tris(o-cresyl)-phosphate
  • Tris(o-methylphenyl)phosphate
  • Tris(o-tolyl) phosphate
  • Tris(o-tolyl)-phosphate
  • Trojkrezylu fosforan
  • Trojkrezylu fosforan [Polish]
  • UNII-X8II18JD0A

Systematic Names

  • o-Tolyl phosphate
  • Phosphoric acid, tri-o-tolyl ester
  • Phosphoric acid, tris(2-methylphenyl) ester
  • Tri-o-tolyl phosphate

Superlist Names

  • Phosphoric acid, tris(2-methylphenyl) ester
  • Tri-o-cresyl phosphate
  • Tri-ortho-cresylphosphate
  • Tricresyl phosphate (1% or more of the ortho isomer)
  • Tricresyl phosphate (less than 1% of the ortho isomer)
  • Triorthocresyl phosphate

Registry Numbers

CAS Registry Number

  • 78-30-8

FDA UNII

  • X8II18JD0A

Other Registry Number

  • 1336-40-9

System Generated Number

  • 0000078308

Structure Descriptors

InChI

1S/C21H21O4P/c1-16-10-4-7-13-19(16)23-26(22,24-20-14-8-5-11-17(20)2)25-21-15-9-6-12-18(21)3/h4-15H,1-3H3

InChIKey

YSMRWXYRXBRSND-UHFFFAOYSA-N

Smiles

Cc1ccccc1OP(=O)(Oc2ccccc2C)Oc3ccccc3C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 skin 1500mg/kg (1500mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: MUSCLE WEAKNESS

SENSE ORGANS AND SPECIAL SENSES: MIOSIS (PUPILLARY CONSTRICTION): EYE
Neurobehavioral Toxicology and Teratology. Vol. 5, Pg. 431, 1983.
cat LDLo subcutaneous 185mg/kg (185mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Bulletin of the Johns Hopkins Hospital. Vol. 52, Pg. 39, 1933.
chicken LD50 intraperitoneal 500mg/kg (500mg/kg)   Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
chicken LD50 oral 500mg/kg (500mg/kg)   Environmental Quality and Safety. Vol. 3, Pg. 173, 1974.
dog LDLo subcutaneous 100mg/kg (100mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
guinea pig LDLo subcutaneous 300mg/kg (300mg/kg) MUSCULOSKELETAL: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED

PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
mammal (species unspecified) LD50 oral 400mg/kg (400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 39(4), Pg. 86, 1974.
monkey LDLo subcutaneous 1gm/kg (1000mg/kg) AUTONOMIC NERVOUS SYSTEM: OTHER (DIRECT) PARASYMPATHOMIMETIC

BEHAVIORAL: FOOD INTAKE (ANIMAL)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 165, Pg. 84, 1972.
mouse LD50 intraperitoneal 1960mg/kg (1960mg/kg)   Toxicology and Applied Pharmacology. Vol. 2, Pg. 495, 1960.
mouse LD50 oral 900mg/kg (900mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Toxicology and Applied Pharmacology. Vol. 7, Pg. 227, 1965.
mouse LDLo subcutaneous 12500mg/kg (12500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

LUNGS, THORAX, OR RESPIRATION: CYANOSIS
"Beitrag zur Toxikologie Technischer Weichmachungsmittel, Dissertation," Eller, H., Pharmakologischen Institut der Universitat Wurzburg, Fed. Rep. Ger., 1937Vol. -, Pg. -, 1937.
rabbit LD50 skin > 3700mg/kg (3700mg/kg)   Toxicology and Applied Pharmacology. Vol. 41, Pg. 291, 1977.
rabbit LDLo intramuscular 135mg/kg (135mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 171, Pg. 439, 1933.
rabbit LDLo intraperitoneal 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: TREMOR
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
rabbit LDLo intravenous 100mg/kg (100mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
rabbit LDLo oral 100mg/kg (100mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

BEHAVIORAL: MUSCLE WEAKNESS
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
rabbit LDLo subcutaneous 100mg/kg (100mg/kg) LUNGS, THORAX, OR RESPIRATION: STRUCTURAL OR FUNCTIONAL CHANGE IN TRACHEA OR BRONCHI

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 168, Pg. 473, 1932.
rat LD50 intraperitoneal 2500mg/kg (2500mg/kg)   Advances in Pest Control Research. Vol. 4, Pg. 117, 1961.
rat LD50 oral 1160mg/kg (1160mg/kg)   Toxicologist. Vol. 4, Pg. 55, 1984.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 11 deg C   EXP
Boiling Point 410 deg C   EXP
log P (octanol-water) 6.340 (none)   EST
Water Solubility 0.102 mg/L 25 EST
Henry's Law Constant 5.35E-08 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.37E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.