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Substance Name: Romurtide [INN:JAN]
RN: 78113-36-7
UNII: SUP956TPT6
InChIKey: FKHUGQZRBPETJR-RXSRXONKSA-N

Note

  • A synthetic muramyl dipeptide analog; stimulates chemotactic mobility, phagocytic activity & superoxide production by neutrophils in mice; used for the prophylaxis of leukocytopenia during radiation therapy.

Molecular Formula

  • C43-H78-N6-O13

Molecular Weight

  • 887.118
 

Classification Codes

  • Adjuvants, Immunologic
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Romurtide
  • Romurtide [INN:JAN]

Synonyms

  • 2-Acetamido-3-O-((R)-1-(((S)-1-(((R)-1-carbamoyl-3-(((S)-1-carboxy-5-stearamidopentyl)carbamoyl)propyl)carbamoyl)ethyl)carbamoyl)ethyl)-2-deoxy-D-glucopyranose
  • BRN 4288462
  • CCRIS 1220
  • DJ-7041
  • MDP-lys(L18)
  • Muroctasin
  • N(alpha)-(N-Acetylmuram yl-alanyl-isoglutaminyl)-N(epsilon)stearoyllysine
  • N(sup 2)-((N-Acetylmuramoyl)-L-alanyl-D-isoglutaminyl)-N(sup 6)-stearoyl-L-lysine
  • Nopia
  • Romurtida
  • Romurtida [INN-Spanish]
  • Romurtide
  • Romurtidum
  • Romurtidum [INN-Latin]
  • UNII-SUP956TPT6

Systematic Names

  • 2-Acetamido-3-O-((R)-1-(((S)-1-(((R)-1-carbamoyl-3-(((S)-1-carboxy-5-stearamidopentyl)carbamoyl)propyl)carbamoyl)ethyl)carbamoyl)ethyl)-2-deoxy-D-glucopyranose
  • L-Lysine, N(sup 2),(N(sup 2)-(N-(N-acetylmuramoyl)-L-alanyl)-D-alpha-glutaminyl)-N(sup 6)-(1-oxooctadecyl)-
  • L-Lysine, N2-(N2-(N-(N-acetylmuramoyl)-L-alanyl)-D-alpha-glutaminyl)-N6-(1-oxooctadecyl)-
  • Muroctasin

Registry Numbers

CAS Registry Number

  • 78113-36-7

FDA UNII

  • SUP956TPT6

System Generated Number

  • 0078113367

Structure Descriptors

InChI

1S/C43H78N6O13/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23-34(52)45-26-21-20-22-32(42(58)59)48-35(53)25-24-31(39(44)55)49-40(56)28(2)46-41(57)29(3)61-38-36(47-30(4)51)43(60)62-33(27-50)37(38)54/h28-29,31-33,36-38,43,50,54,60H,5-27H2,1-4H3,(H2,44,55)(H,45,52)(H,46,57)(H,47,51)(H,48,53)(H,49,56)(H,58,59)/t28-,29+,31+,32+,33+,36+,37+,38+,43?/m0/s1

InChIKey

FKHUGQZRBPETJR-RXSRXONKSA-N

Smiles

C[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](CCC(=O)N[C@@H](C(=O)O)CCCCNC(CCCCCCCCCCCCCCCCC)=O)C(=O)N)O[C@H]1[C@@H]([C@H](O[C@@H]([C@@H]1NC(C)=O)O)CO)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 200mg/kg (200mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

SKIN AND APPENDAGES (SKIN): "DERMATITIS, IRRITATIVE: AFTER SYSTEMIC EXPOSURE"
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1022, 1988.
mouse LD50 oral > 600mg/kg (600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.
mouse LD50 subcutaneous 436mg/kg (436mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: IRRITABILITY
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1022, 1988.
rat LD50 intravenous > 90mg/kg (90mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.
rat LD50 oral > 600mg/kg (600mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 22, Pg. 967, 1991.
rat LD50 subcutaneous 761mg/kg (761mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: IRRITABILITY
Arzneimittel-Forschung. Drug Research. Vol. 38, Pg. 1022, 1988.