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Substance Name: Tesevatinib [USAN:INN]
RN: 781613-23-8
UNII: F6XM2TN5A1
InChIKey: HVXKQKFEHMGHSL-QKDCVEJESA-N

Note

  • NCI: An orally bioavailable small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Tesevatinib binds to and inhibits several tyrosine receptor kinases that play major roles in tumor cell proliferation and tumor vascularization, including epidermal growth factor receptor (EGFR; ERBB1), epidermal growth factor receptor 2 (HER2; ERBB2), vascular endothelial growth factor receptor (VEGFR), and ephrin B4 (EphB4). This may result in the inhibition of tumor growth and angiogenesis, and tumor regression. (NCI Thesaurus)

Molecular Weight

  • 491.3915
 

Classification Code

  • Treatment of Cancer and Polycystic Kidney Disease
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Names and Synonyms

Name of Substance

  • Tesevatinib [USAN:INN]
  • Xl-647

Synonyms

  • 4-Quinazolinamine, N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aalpha,5beta,6aalpha)-octahydro-2-methylcyclopenta(c)pyrrol-5-yl)methoxy)-
  • EXEL 7647
  • Exel-7647
  • KD 019
  • KD-019
  • KD019
  • N-(3,4-Dichloro-2-fluorophenyl)-6-methoxy-7-(((3ar,6as)-2-methyloctahydrocyclopenta(c)pyrrol-5-yl)methoxy)quinazolin-4-amine
  • Tesevatinib
  • UNII-F6XM2TN5A1
  • XL 647
  • Xl647

Registry Numbers

CAS Registry Number

  • 781613-23-8

FDA UNII

  • F6XM2TN5A1

Other Registry Numbers

  • 874286-84-7
  • 950774-05-7

System Generated Number

  • 0781613238

Structure Descriptors

InChI

1S/C24H25Cl2FN4O2/c1-31-9-14-5-13(6-15(14)10-31)11-33-21-8-19-16(7-20(21)32-2)24(29-12-28-19)30-18-4-3-17(25)22(26)23(18)27/h3-4,7-8,12-15H,5-6,9-11H2,1-2H3,(H,28,29,30)/t13-,14-,15+

InChIKey

HVXKQKFEHMGHSL-QKDCVEJESA-N

Smiles

CN1C[C@H]2C[C@H](C[C@H]2C1)COc3cc4c(cc3OC)c(ncn4)Nc5ccc(c(c5F)Cl)Cl