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Substance Name: Paroxetine hydrochloride [USP]
RN: 78246-49-8
UNII: 3I3T11UD2S
InChIKey: GELRVIPPMNMYGS-RVXRQPKJSA-N

Note

  • A serotonin uptake inhibitor that is effective in the treatment of depression.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C19-H20-F-N-O3.Cl-H

Molecular Weight

  • 365.8299
 

Names and Synonyms

Name of Substance

  • Paroxetine hydrochloride
  • Paroxetine hydrochloride [USP]

Synonyms

  • (-)-(3S,4R)-4-(p-Fluorophenyl)-3-((3,4-methylenedioxy)phenoxy)-methyl)piperidine hydrochloride
  • Aropax
  • Aropax 20
  • BRL 29060 hydrochloride
  • BRL 29060A
  • BRL29060A
  • Paroxat
  • Paroxetine HCl
  • Paroxetine hydrochloride
  • Paxil
  • Paxil CR
  • Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, hydrochloride, (3S,4R)-
  • SDB 7175
  • Seroxat
  • UNII-3I3T11UD2S

Systematic Name

  • Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-, hydrochloride, (3S-trans)-

Registry Numbers

CAS Registry Number

  • 78246-49-8

FDA UNII

  • 3I3T11UD2S

Related Registry Number

  • 61869-08-7 (Parent)

System Generated Number

  • 0078246498

Molecular Formulas

Molecular Formula

  • C19-H20-F-N-O3.Cl-H

Molecular Formula Fragments

  • C19-H20-F-N-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;/h1-6,9,14,17,21H,7-8,10-12H2;1H/t14-,17-;/m0./s1

InChIKey

GELRVIPPMNMYGS-RVXRQPKJSA-N

Smiles

Cl.Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 625ug/kg (0.625mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: HEADACHE
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(Suppl,
man TDLo oral 3654ug/kg/14D (3.654mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 28(Suppl,
mouse LD50 intravenous 42mg/kg (42mg/kg)   Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
mouse LD50 oral 378mg/kg (378mg/kg)   Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
rat LD50 intravenous 30mg/kg (30mg/kg)   Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
rat LD50 oral 415mg/kg (415mg/kg)   Acta Psychiatrica Scandinavica, Supplementum. Vol. 350, Pg. 31, 1989.
women TDLo oral 7400ug/kg/3W- (7.4mg/kg) BEHAVIORAL: WAKEFULNESS

BEHAVIORAL: AGGRESSION

BEHAVIORAL: TOXIC PSYCHOSIS
Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 36, Pg. 721, 1997.