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Substance Name: Tiacrilast [USAN:INN]
RN: 78299-53-3
UNII: 74L3DXN051
InChIKey: VHFPVEGFRVEDBK-SNAWJCMRSA-N

Classification Codes

  • Anti-Allergic
  • Drug / Therapeutic Agent

Molecular Formula

  • C12-H10-N2-O3-S

Molecular Weight

  • 262.288
 
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Names and Synonyms

Name of Substance

  • Tiacrilast
  • Tiacrilast [USAN:INN]

Synonyms

  • (E)-3-(6-(Methylthio)-4-oxo-3(4H)-quinazolinyl)-2-propenoic acid
  • (E)-6-(Methylthio)-4-oxo-3(4H)-quinazolineacrylic acid
  • 2-Propenoic acid, 3-(6-(methylthio)-4-oxo-3(4H)-quinazolinyl)-, (E)-
  • BRN 5752117
  • Ro 22-3747
  • Ro 22-3747/000
  • Tiacrilast
  • Tiacrilastum
  • Tiacrilastum [INN-Latin]
  • UNII-74L3DXN051

Systematic Name

  • 2-Propenoic acid, 3-(6-(methylthio)-4-oxo-3(4H)-quinazolinyl)-, (E)-

Registry Numbers

CAS Registry Number

  • 78299-53-3

FDA UNII

  • 74L3DXN051

System Generated Number

  • 0078299533

Structure Descriptors

InChI

1S/C12H10N2O3S/c1-18-8-2-3-10-9(6-8)12(17)14(7-13-10)5-4-11(15)16/h2-7H,1H3,(H,15,16)/b5-4+

InChIKey

VHFPVEGFRVEDBK-SNAWJCMRSA-N

Smiles

c12c(ncn(c1=O)\C=C\C(O)=O)ccc(c2)SC

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral > 1gm/kg (1000mg/kg)   Drugs of the Future. Vol. 10, Pg. 131, 1985.
rabbit LD50 oral > 2gm/kg (2000mg/kg)   Drugs of the Future. Vol. 10, Pg. 131, 1985.
rat LD50 oral > 4gm/kg (4000mg/kg)   Drugs of the Future. Vol. 10, Pg. 131, 1985.