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Substance Name: Abexinostat [USAN:INN]
RN: 783355-60-2
UNII: IYO470654U
InChIKey: MAUCONCHVWBMHK-UHFFFAOYSA-N

Note

  • NCI: A novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase (HDAC) with potential antineoplastic activity. Abexinostat inhibits several isoforms of HDAC, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling; the selective transcription of tumor suppressor genes; and the tumor suppressor protein-mediated inhibition of tumor cell division and induction of tumor cell apoptosis. HDAC, upregulated in many tumor types, is an an enzyme that is responsible for the deacetylation of chromatin histone proteins. (NCI Thesaurus

Molecular Formula

  • C21-H23-N3-O5

Molecular Weight

  • 397.4287
 

Classification Codes

  • Antineoplastic
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
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Names and Synonyms

Name of Substance

  • Abexinostat [USAN:INN]

Synonyms

  • Abexinostat
  • CRA 024781
  • CRA-024781
  • PCI 24781
  • PCI-24781
  • S78454
  • UNII-IYO470654U

Systematic Name

  • 2-Benzofurancarboxamide, 3-((dimethylamino)methyl)-N-(2-(4-((hydroxyamino)carbonyl)phenoxy)ethyl)-

Registry Numbers

CAS Registry Number

  • 783355-60-2

FDA UNII

  • IYO470654U

Other Registry Numbers

  • 883970-69-2
  • 942630-54-8

System Generated Number

  • 0783355602

Structure Descriptors

InChI

1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)

InChIKey

MAUCONCHVWBMHK-UHFFFAOYSA-N

Smiles

CN(C)Cc1c2ccccc2oc1C(=O)NCCOc3ccc(cc3)C(=O)NO