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Substance Name: Milrinone [USAN:USP:INN:BAN]
RN: 78415-72-2
UNII: JU9YAX04C7
InChIKey: PZRHRDRVRGEVNW-UHFFFAOYSA-N

Note

  • A positive inotropic cardiotonic agent with vasodilator properties. It inhibits cAMP phosphodiesterase type 3 activity in myocardium and vascular smooth muscle. Milrinone is a derivative of amrinone and has 20-30 times the inotropic potency of amrinone.

Molecular Formula

  • C12-H9-N3-O

Molecular Weight

  • 211.223
 

Classification Codes

  • Cardiotonic
  • Cardiotonic Agents
  • Cardiovascular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Hematologic Agents
  • Phosphodiesterase 3 Inhibitors
  • Phosphodiesterase Inhibitors
  • Platelet Aggregation Inhibitors
  • Protective Agents
  • Vasodilator Agents
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Names and Synonyms

Name of Substance

  • Milrinone
  • Milrinone [USAN:USP:INN:BAN]

MeSH Heading

  • Milrinone

Synonyms

  • (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-
  • 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile
  • BRN 3546821
  • CCRIS 3795
  • EINECS 278-903-6
  • Milrinona
  • Milrinona [Spanish]
  • Milrinone
  • Milrinonum
  • Milrinonum [Latin]
  • Primacor
  • UNII-JU9YAX04C7
  • Win 47,203-2
  • WIN 47203-2
  • YM 018

Systematic Names

  • (3,4'-Bipyridine)-5-carbonitrile, 1,6-dihydro-2-methyl-6-oxo-
  • (3,4'-Bipyridine)-5-carbonitrile, 6-dihydro-2-methyl-6-oxo-
  • Milrinone

Registry Numbers

CAS Registry Number

  • 78415-72-2

FDA UNII

  • JU9YAX04C7

System Generated Number

  • 0078415722

Structure Descriptors

InChI

1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

InChIKey

PZRHRDRVRGEVNW-UHFFFAOYSA-N

Smiles

c1(c2ccncc2)cc(c(=O)[nH]c1C)C#N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD intravenous > 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)"

CARDIAC: OTHER CHANGES
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 21, Pg. 2891, 1993.
mouse LD50 intravenous 79mg/kg (79mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
mouse LD50 oral 137mg/kg (137mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
mouse LD50 subcutaneous 62mg/kg (62mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 652, 1996.
rabbit LD50 intravenous 44400ug/kg (44.4mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA

CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION
New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
rabbit LD50 oral 40mg/kg (40mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
rat LD50 intravenous 73mg/kg (73mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
rat LD50 oral 91mg/kg (91mg/kg)   New Cardiovascular Drugs. Vol. 3, Pg. 245, 1985.
rat LD50 subcutaneous 58mg/kg (58mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 652, 1996.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point >300 deg C   EXP
log P (octanol-water) 1.170 (none)   EST
Atmospheric OH Rate Constant 1.56E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.