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Substance Name: Bermoprofen [INN]
RN: 78499-27-1
UNII: CWU66767HF
InChIKey: REHLODZXMGOGQP-UHFFFAOYSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C18-H16-O4

Molecular Weight

  • 296.32
 
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Names and Synonyms

Name of Substance

  • Bermoprofen
  • Bermoprofen [INN]

Synonyms

  • 10,11-Dihydro-alpha,8-dimethyl-11-oxo-dibenz(b,f)oxepin-2-acetic acid
  • 2-(8-Methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic
  • AD-1590
  • Bermoprofen
  • Bermoprofene
  • Bermoprofene [French]
  • Bermoprofeno
  • Bermoprofeno [Spanish]
  • Bermoprofenum
  • Bermoprofenum [Latin]
  • BRN 4815717
  • dl-2-(8-Methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)propionic acid
  • Propionic acid, 2-(8-methyl-10,11-dihydro-11-oxodibenz(b,f)oxepin-2-yl)-
  • UNII-CWU66767HF

Systematic Name

  • Dibenz(b,f)oxepin-2-acetic acid, 10,11-dihydro-alpha,8-dimethyl-11-oxo-

Registry Numbers

CAS Registry Number

  • 78499-27-1

FDA UNII

  • CWU66767HF

Other Registry Number

  • 72619-34-2

System Generated Number

  • 0078499271

Structure Descriptors

InChI

1S/C18H16O4/c1-10-3-5-16-13(7-10)9-15(19)14-8-12(11(2)18(20)21)4-6-17(14)22-16/h3-8,11H,9H2,1-2H3,(H,20,21)

InChIKey

REHLODZXMGOGQP-UHFFFAOYSA-N

Smiles

c12c(Oc3ccc(cc3CC2=O)C)ccc(c1)[C@@H](C(O)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 191mg/kg (191mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: NORMOCYTIC ANEMIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse LD50 oral 212mg/kg (212mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: NORMOCYTIC ANEMIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
mouse LD50 subcutaneous 387mg/kg (387mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LD50 intraperitoneal 391mg/kg (391mg/kg) BLOOD: NORMOCYTIC ANEMIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LD50 oral 147mg/kg (147mg/kg) BEHAVIORAL: ANALGESIA Journal of Medicinal Chemistry. Vol. 25, Pg. 1065, 1982.
rat LD50 oral 147mg/kg (147mg/kg)   European Patent Application. Vol. #0003893,
rat LD50 subcutaneous 483mg/kg (483mg/kg) BLOOD: NORMOCYTIC ANEMIA

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 16, Pg. 2701, 1988.
rat LDLo intravenous 160mg/kg (160mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 108, Pg. 788, 1988.