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Substance Name: Terbinafine hydrochloride [USP:JAN]
RN: 78628-80-5
UNII: 012C11ZU6G
InChIKey: BWMISRWJRUSYEX-SZKNIZGXSA-N

Note

  • Synthetic antifungal agent inhibiting fungal squalene epoxidase.

Molecular Formula

  • C21-H25-N.Cl-H

Molecular Weight

  • 327.8964
 

Classification Codes

  • Antifungal
  • Drug / Therapeutic Agent
  • Human Data
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Terbinafine hydrochloride [USP:JAN]

Synonyms

  • (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine hydrochloride
  • Athletes foot
  • DRG-0286
  • EC 616-640-4
  • Lamisil
  • Lamisil AT
  • Lamisil Krem
  • SF 86-327 hydrochloride
  • Terbinafina
  • Terbinafina [Spanish]
  • Terbinafine HCl
  • Terbinafine hydrochloride
  • Terbinafinum
  • Terbinafinum [Latin]
  • UNII-012C11ZU6G

Systematic Names

  • (2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine hydrochloride (1:1)
  • 1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, (E)-, monohydrochloride

Registry Numbers

CAS Registry Number

  • 78628-80-5

FDA UNII

  • 012C11ZU6G

System Generated Number

  • 0078628805

Molecular Formulas

Molecular Formula

  • C21-H25-N.Cl-H

Molecular Formula Fragments

  • C21-H25-N
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

InChIKey

BWMISRWJRUSYEX-SZKNIZGXSA-N

Smiles

CC(C)(C)C#C/C=C/CN(C)Cc1cccc2c1cccc2.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 subcutaneous > 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7888, 1990.
rat LD50 skin > 2gm/kg (2000mg/kg) SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: ATAXIA

BLOOD: CHANGES IN SPLEEN
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7922, 1990.
rat LD50 subcutaneous > 2gm/kg (2000mg/kg) BLOOD: CHANGES IN SPLEEN

BEHAVIORAL: ATAXIA

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 7922, 1990.
women TDLo oral 210mg/kg/6W-I (210mg/kg) SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE Lancet. Vol. 339, Pg. 1483, 1992.