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Substance Name: Posatirelin [INN]
RN: 78664-73-0
UNII: 78U6302ARL
InChIKey: DPNGIIPSQYKWQA-AVGNSLFASA-N

Note

  • Stimulates oxygen consumption.

Classification Codes

  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C17-H28-N4-O4

Molecular Weight

  • 352.432
 
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Names and Synonyms

Name of Substance

  • Posatirelin
  • Posatirelin [INN]

Synonyms

  • (-)-(2S)-N-(1S)-1-((2S)-2-Carbamoyl-1-pyrrolidinyl)carbonyl-3-(methylbutyl)-6-oxopipecolamide
  • (2S)-N((1S)-1-(((2S)-2-Carbamoyl-1-pyrrolidinyl)carbonyl)-3-methylbutyl)-6-oxopipecolamide
  • (S)-L-Leucyl-N-((6-oxo-2-piperidinyl)carbonyl)-L-prolinamide
  • BRN 6006446
  • L-6-Ketopiperidine-2-carbonyl-leucyl-L-prolin-amide
  • L-Pyro-2-aminoadipyl-L-leucyl-L-prolinamide
  • Posatirelin
  • Posatirelina
  • Posatirelina [INN-Spanish]
  • Posatireline
  • Posatireline [INN-French]
  • Posatirelinum
  • Posatirelinum [INN-Latin]
  • RGH-2202
  • UNII-78U6302ARL

Systematic Names

  • (2S)-N((1S)-1-(((2S)-2-Carbamoyl-1-pyrrolidinyl)carbonyl)-3-methylbutyl)-6-oxopipecolamide
  • L-Prolinamide, N-((6-oxo-2-piperidinyl)carbonyl)-L-leucyl-, (S)-

Registry Numbers

CAS Registry Number

  • 78664-73-0

FDA UNII

  • 78U6302ARL

System Generated Number

  • 0078664730

Structure Descriptors

InChI

1S/C17H28N4O4/c1-10(2)9-12(17(25)21-8-4-6-13(21)15(18)23)20-16(24)11-5-3-7-14(22)19-11/h10-13H,3-9H2,1-2H3,(H2,18,23)(H,19,22)(H,20,24)/t11-,12-,13-/m0/s1

InChIKey

DPNGIIPSQYKWQA-AVGNSLFASA-N

Smiles

C1CC[C@H](N1C([C@@H](NC([C@@H]1CCCC(N1)=O)=O)CC(C)C)=O)C(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 4gm/kg (4000mg/kg)   Drugs of the Future. Vol. 13, Pg. 420, 1988.
mouse LD50 intravenous 2260mg/kg (2260mg/kg)   Drugs of the Future. Vol. 13, Pg. 420, 1988.
rat LD50 intraperitoneal 3gm/kg (3000mg/kg)   Drugs of the Future. Vol. 13, Pg. 420, 1988.
rat LD50 intravenous 1140mg/kg (1140mg/kg)   Drugs of the Future. Vol. 13, Pg. 420, 1988.