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Substance Name: Tiracizine hydrochloride
RN: 78816-67-8
UNII: GB5HGM31RA
InChIKey: XJWABFCDXKZWPV-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C21-H25-N3-O3.Cl-H

Molecular Weight

  • 403.9074
 
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Names and Synonyms

Results Name

  • Tiracizine hydrochloride

Name of Substance

  • Bonnecor
  • Tiracizine hydrochloride

Synonyms

  • 3-Carbethoxyamino-5-dimethylaminoacetyl-10,11-dihydrodibenz(b,f)azepine hydrochloride
  • AWD 19-166
  • Bonnecor
  • Ethyl (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)carbamate monohydrochloride
  • GS 015
  • UNII-GB5HGM31RA

Systematic Names

  • 5H-Dibenz(b,f)azepine-3-carbamic acid, 10,11-dihydro-5-((dimethylamino)acetyl)-, ethyl ester,monohydrochloride
  • Carbamic acid, (5-((dimethylamino)acetyl)-10,11-dihydro-5H-dibenz(b,f)azepin-3-yl)-, ethyl ester, monohydrochloride

Registry Numbers

CAS Registry Number

  • 78816-67-8

FDA UNII

  • GB5HGM31RA

System Generated Number

  • 0078816678

Molecular Formulas

Molecular Formula

  • C21-H25-N3-O3.Cl-H

Molecular Formula Fragments

  • C21-H25-N3-O3
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H25N3O3.ClH/c1-4-27-21(26)22-17-12-11-16-10-9-15-7-5-6-8-18(15)24(19(16)13-17)20(25)14-23(2)3;/h5-8,11-13H,4,9-10,14H2,1-3H3,(H,22,26);1H

InChIKey

XJWABFCDXKZWPV-UHFFFAOYSA-N

Smiles

CCOC(=O)Nc1ccc2c(c1)N(c3ccccc3CC2)C(=O)CN(C)C.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 5400ug/kg (5.4mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Pharmazie. Vol. 40, Pg. 871, 1985.
mouse LD50 oral 48mg/kg (48mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Pharmazie. Vol. 40, Pg. 871, 1985.
rat LD50 intravenous 10900ug/kg (10.9mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Pharmazie. Vol. 40, Pg. 871, 1985.
rat LD50 oral 78mg/kg (78mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: ATAXIA
Pharmazie. Vol. 40, Pg. 871, 1985.