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Substance Name: Fosfomycin tromethamine [USAN]
RN: 78964-85-9
UNII: 7FXW6U30GY
InChIKey: QZJIMDIBFFHQDW-LMLSDSMGSA-N

Note

  • An antibiotic produced by Streptomyces fradiae.

Molecular Formula

  • C4-H11-N-O3.C3-H7-O4-P

Molecular Weight

  • 259.1932
 

Classification Codes

  • Anti-Infective Agents
  • Antibacterial
  • Drug / Therapeutic Agent
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Names and Synonyms

Name of Substance

  • Fosfomycin tromethamine
  • Fosfomycin tromethamine [USAN]
  • Fosfomycin tromethanol

Synonyms

  • (1R,2S)-(1,2-Epoxypropyl)phosphonic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • EINECS 279-018-8
  • Fosfomycin compd. with trometamol
  • Fosfomycin trometamol salt
  • Fosfomycin tromethamine
  • Fosfotricin
  • Monurol
  • Monurol Sachet
  • Tromethamine-fosfomycin
  • UNII-7FXW6U30GY
  • Z 1282

Systematic Names

  • (2R-cis)-(3-Methyloxiranyl)phosphonic acid, compound with 2-amino-2-(hydroxymethyl)propane-1,3-diol (1:1)
  • Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

Registry Numbers

CAS Registry Number

  • 78964-85-9

FDA UNII

  • 7FXW6U30GY

System Generated Number

  • 0078964859

Molecular Formulas

Molecular Formula

  • C4-H11-N-O3.C3-H7-O4-P

Molecular Formula Fragments

  • C3-H7-O4-P
  • C4-H11-N-O3
  • COMPONENT

Structure Descriptors

InChI

InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/m.0/s1

InChIKey

QZJIMDIBFFHQDW-LMLSDSMGSA-N

Smiles

C[C@@H]1O[C@@H]1P(=O)(O)[O-].[NH3+]C(CO)(CO)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 unreported > 10gm/kg (10000mg/kg)   Drugs of the Future. Vol. 13, Pg. 77, 1988.
rat LD50 unreported > 10gm/kg (10000mg/kg)   Drugs of the Future. Vol. 13, Pg. 77, 1988.