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Substance Name: Calpain
RN: 78990-62-2


  • Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC

Molecular Formula

  • Unspecified
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Names and Synonyms

MeSH Heading

  • Calpain


  • Calcium-activated neutral proteinase
  • Procalpain
  • Proteinase, calcium-activated neutral

Systematic Name

  • Calpain

Registry Numbers

CAS Registry Number

  • 78990-62-2

Other Registry Number

  • 91608-89-8

System Generated Number

  • 0078990622