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Substance Name: Acrylamide
RN: 79-06-1
UNII: 20R035KLCI
InChIKey: HRPVXLWXLXDGHG-UHFFFAOYSA-N

Note

  • A colorless, odorless, highly water soluble vinyl monomer formed from the hydration of acrylonitrile. It is primarily used in research laboratories for electrophoresis, chromatography, and electron microscopy and in the sewage and wastewater treatment industries.

Molecular Formula

  • C3-H5-N-O

Molecular Weight

  • 71.0785
 

Classification Codes

Classification Codes

  • Mutation Data
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 5000 lb
  • Threshold Planning Quantity (TPQ) = 1000/10000 lb
  • TWA (0.3 mg/m3); skin
  • TWA 0.03 mg/m3 (inhalable fraction and vapor); skin; Confirmed animal carcinogen with unknown relevance to humans

Names and Synonyms

Name of Substance

  • Acrylamide

MeSH Heading

  • Acrylamide

Synonyms

  • 2-Propenamide
  • 4-02-00-01471 (Beilstein Handbook Reference)
  • AAM
  • Acrylagel
  • Acrylamide
  • Acrylic acid amide
  • Acrylic amide
  • AI3-04119
  • Akrylamid
  • Akrylamid [Czech]
  • Amid kyseliny akrylove
  • Amid kyseliny akrylove [Czech]
  • Amresco Acryl-40
  • BRN 0605349
  • CCRIS 7
  • EC 201-173-7
  • EINECS 201-173-7
  • Ethylenecarboxamide
  • HSDB 191
  • NSC 7785
  • Optimum
  • Propenamide
  • Propeneamide
  • Propenoic acid amide
  • RCRA waste number U007
  • UNII-20R035KLCI
  • Vinyl amide

Systematic Names

  • 2-Propenamide
  • Acrylamide

Superlist Names

  • 2-Propenamide
  • Acrylamide
  • Acrylamide solution
  • Acrylamide solution (50% or less)
  • Acrylamide [UN2074] [Poison]
  • RCRA waste no. U007
  • UN2074

Registry Numbers

CAS Registry Number

  • 79-06-1

FDA UNII

  • 20R035KLCI

Other Registry Number

  • 1198293-68-3

System Generated Number

  • 0000079061

Structure Descriptors

InChI

1S/C3H5NO/c1-2-3(4)5/h2H,1H2,(H2,4,5)

InChIKey

HRPVXLWXLXDGHG-UHFFFAOYSA-N

Smiles

C(C=C)(N)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 150mg/kg (150mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 172, 1964.
guinea pig LD50 subcutaneous 170mg/kg (170mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

GASTROINTESTINAL: NAUSEA OR VOMITING
Medicina del Lavoro. Industrial Medicine. Vol. 47, Pg. 192, 1956.
guinea pig LD50 unreported 173mg/kg (173mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
mammal (species unspecified) LD50 oral 100mg/kg (100mg/kg)   Kagaku to Seibutsu. Chemistry and Biology. Vol. 17, Pg. 495, 1979.
mammal (species unspecified) LDLo intravenous 190mg/kg (190mg/kg)   Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. Vol. 153, Pg. 895, 1911.
mouse LD50 intraperitoneal 170mg/kg (170mg/kg)   Toxicology and Applied Pharmacology. Vol. 33, Pg. 142, 1975.
mouse LD50 oral 107mg/kg (107mg/kg)   Archives of Toxicology. Vol. 47, Pg. 179, 1981.
mouse LD50 unreported 156mg/kg (156mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: TREMOR
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
quail LD50 oral 186mg/kg (186mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Journal of Toxicology and Environmental Health. Vol. 7, Pg. 935, 1981.
rabbit LD50 oral 150mg/kg (150mg/kg)   Toxicology and Applied Pharmacology. Vol. 6, Pg. 172, 1964.
rabbit LD50 skin 1680uL/kg (1.68mL/kg) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 115, 1990.
rabbit LD50 unreported 280mg/kg (280mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.
rat LD50 intraperitoneal 90mg/kg (90mg/kg)   Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 36, Pg. 58, 1975.
rat LD50 oral 124mg/kg (124mg/kg)   Archives des Maladies Professionnelles de Medecine du Travail et de Securite Sociale. Vol. 36, Pg. 58, 1975.
rat LD50 skin 400mg/kg (400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(10), Pg. 73, 1979.
rat LD50 skin 400mg/kg (400mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(10), Pg. 73, 1979.
rat LD50 skin 400mg/kg (400mg/kg) BLOOD: OTHER CHANGES Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 44(10), Pg. 73, 1979.
rat LD50 unreported 208mg/kg (208mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 43(9), Pg. 38, 1978.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 84.5 deg C   EXP
Boiling Point 192.6 deg C   EXP
log P (octanol-water) -0.67 (none)   EXP
Water Solubility 6.40E+05 mg/L 25 EXP
Vapor Pressure 0.007 mm Hg 25 EXP
Henry's Law Constant 1.00E-09 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.12E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.