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Substance Name: Pempidine [INN:BAN]
RN: 79-55-0
UNII: N5I18JI9D6
InChIKey: XULIXFLCVXWHRF-UHFFFAOYSA-N

Note

  • A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has largely been supplanted for that purpose by more specific drugs.

Molecular Formula

  • C10-H21-N

Molecular Weight

  • 155.283
 

Classification Codes

  • Antihypertensive Agents
  • Autonomic Agents
  • Cardiovascular Agents
  • Cholinergic Agents
  • Cholinergic Antagonists
  • Drug / Therapeutic Agent
  • Ganglionic Blockers
  • Neurotransmitter Agents
  • Nicotinic Antagonists
  • Peripheral Nervous System Agents
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Names and Synonyms

Name of Substance

  • Pempidine
  • Pempidine [INN:BAN]

MeSH Heading

  • Pempidine

Synonyms

  • 1,2,2,6,6-Pentamethylpiperidine
  • EINECS 201-211-2
  • M+B 4486
  • Pempidina
  • Pempidina [DCIT]
  • Pempidine
  • Pempidinum
  • Pempidinum [INN-Latin]
  • Perolysen
  • Pyrilene
  • Tenormal
  • UNII-N5I18JI9D6

Systematic Names

  • 1,2,2,6,6-Pentamethylpiperidine
  • Pempidine
  • Piperidine, 1,2,2,6,6-pentamethyl-

Registry Numbers

CAS Registry Number

  • 79-55-0

FDA UNII

  • N5I18JI9D6

System Generated Number

  • 0000079550

Structure Descriptors

InChI

1S/C10H21N/c1-9(2)7-6-8-10(3,4)11(9)5/h6-8H2,1-5H3

InChIKey

XULIXFLCVXWHRF-UHFFFAOYSA-N

Smiles

N1(C(CCCC1(C)C)(C)C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 40mg/kg (40mg/kg)   Nature. Vol. 184, Pg. 1707, 1959.
mouse LD50 oral 275mg/kg (275mg/kg)   Nature. Vol. 184, Pg. 1707, 1959.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point < 25 deg C   EXP
Boiling Point 147 deg C   EXP
pKa Dissociation Constant 11.25 (none) 30 EXP
log P (octanol-water) 2.690 (none)   EST
Atmospheric OH Rate Constant 7.22E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.