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Substance Name: Cyclosporine
RN: 79217-60-0
InChIKey: PMATZTZNYRCHOR-KMSBSJHKSA-N

Note

  • A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).

Molecular Weight

  • 1202.62
 

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Tumor Data
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Names and Synonyms

Results Name

  • Cyclosporine

MeSH Heading

  • Cyclosporine

Synonyms

  • Ciclosporin
  • Cyclosporin
  • Cyclosporine
  • Restasis

Systematic Name

  • Cyclosporin

Superlist Name

  • Cyclosporin

Registry Numbers

CAS Registry Number

  • 79217-60-0

System Generated Number

  • 0079217600

Structure Descriptors

InChI

1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41?,42?,43?,44?,45?,46?,47?,49?,50?,51?,52-/m1/s1

InChIKey

PMATZTZNYRCHOR-KMSBSJHKSA-N

Smiles

N1([C@@H](C(N[C@@H](C(N(CC(N([C@@H](C(N[C@@H](C(N([C@@H](C(=O)N[C@@H](C(N[C@@H](C(N([C@@H](C(N([C@@H](C(N([C@@H](C1=O)C(C)C)C)=O)CC(C)C)C)=O)CC(C)C)C)=O)C)=O)C)CC(C)C)C)=O)C(C)C)=O)CC(C)C)C)=O)C)=O)CC)=O)[C@@H]([C@@H](C\C=C\C)C)O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo unreported 13mg/kg/13W-I (13mg/kg) KIDNEY, URETER, AND BLADDER: OTHER CHANGES

BLOOD: CHANGE IN CLOTTING FACTORS
Lancet. Vol. 2, Pg. 1337, 1984.
mouse LD50 intramuscular 145mg/kg (145mg/kg)   Antibiotiki i Khimioterapiya. Antibiotics and Chemotherapy. Vol. 36(10), Pg. 33, 1991.