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Substance Name: Azelastine hydrochloride [USAN:JAN]
RN: 79307-93-0
UNII: 0L591QR10I
InChIKey: YEJAJYAHJQIWNU-UHFFFAOYSA-N
Note
- Azeptin is azelastine hydrochloride; eye drop formulation effective in relieving symptoms of allergic conjunctivitis.
Molecular Formula
- C22-H24-Cl-N3-O.Cl-H
Molecular Weight
- 418.366
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Formulas
- Structure Descriptors
- Toxicity
Classification Codes
- Anti-Allergic
- Anti-Allergic Agents
- Anti-Asthmatic
- Bronchodilator Agents
- Drug / Therapeutic Agent
- Histamine H1 Antagonists, Non-Sedating
- Lipoxygenase Inhibitors
- Reproductive Effect
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Links to Resources
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Search for this InChIKey on the Web
Names and Synonyms
Name of Substance
- Azelastine hydrochloride [USAN:JAN]
Synonyms
- 1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride
- 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone monohydrochloride
- A 5610
- A-5610
- Allergodil
- Astelin
- Astepro
- Azelastine HCl
- Azelastine hydrochloride
- Azeptin
- E-0659
- Optivar
- Rhinolast
- UNII-0L591QR10I
- W- 979M
- W-2979M
- Zalastine
Systematic Name
- 1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride
Registry Numbers
CAS Registry Number
- 79307-93-0
FDA UNII
- 0L591QR10I
Related Registry Number
- 58581-89-8 (Parent)
System Generated Number
- 0079307930
Molecular Formulas
Molecular Formula
- C22-H24-Cl-N3-O.Cl-H
Molecular Formula Fragments
- C22-H24-Cl-N3-O
- Cl-H
- COMPONENT
Structure Descriptors
InChI
InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1HInChIKey
YEJAJYAHJQIWNU-UHFFFAOYSA-NSmiles
Cl.CN1CCCC(CC1)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | oral | 107mg/kg (107mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ATAXIA BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5235, 1986. |
guinea pig | LD50 | intramuscular | 46200ug/kg (46.2mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
guinea pig | LD50 | intravenous | 23mg/kg (23mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
guinea pig | LD50 | oral | 126mg/kg (126mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
guinea pig | LD50 | subcutaneous | 37300ug/kg (37.3mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
mouse | LD50 | intramuscular | 57200ug/kg (57.2mg/kg) | BEHAVIORAL: ATAXIA BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
mouse | LD50 | intravenous | 25400ug/kg (25.4mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
mouse | LD50 | oral | 143mg/kg (143mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
mouse | LD50 | subcutaneous | 59600ug/kg (59.6mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
rat | LD50 | intramuscular | 115mg/kg (115mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
rat | LD50 | intravenous | 24600ug/kg (24.6mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
rat | LD50 | oral | 580mg/kg (580mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |
rat | LD50 | subcutaneous | 80500ug/kg (80.5mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Kiso to Rinsho. Clinical Report. Vol. 20, Pg. 5231, 1986. |