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Substance Name: Nicaraven [INN]
RN: 79455-30-4
UNII: UD8PEV6JBD
InChIKey: KTXBOOWDLPUROC-UHFFFAOYSA-N

Note

  • An antivasospastic substance.

Molecular Formula

  • C15-H16-N4-O2

Molecular Weight

  • 284.317
 

Classification Codes

  • Antioxidants
  • Drug / Therapeutic Agent
  • Protective Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Nicaraven
  • Nicaraven [INN]

Synonyms

  • (+-)-N,N'-Propylenebis(nicotinamide)
  • (+-)-N,N'-Propylenedinicotinamide
  • 1,2-Bis(nicotinamido)propane
  • AVS
  • CCRIS 7280
  • N,N'-(1-Methyl-1,2-ethanediyl)bis-3-pyridinecarboxamide
  • Nicaraven
  • Nicaravenum
  • Nicaravenum [INN-Latin]
  • UNII-UD8PEV6JBD

Systematic Names

  • (+-)-N,N'-Propylenebis(nicotinamide)
  • 3-Pyridinecarboxamide, N,N'-(1-methyl-1,2-ethanediyl)bis-
  • N,N'-Propylenenicotinamide

Registry Numbers

CAS Registry Number

  • 79455-30-4

FDA UNII

  • UD8PEV6JBD

System Generated Number

  • 0079455304

Structure Descriptors

InChI

1S/C15H16N4O2/c1-11(19-15(21)13-5-3-7-17-10-13)8-18-14(20)12-4-2-6-16-9-12/h2-7,9-11H,8H2,1H3,(H,18,20)(H,19,21)

InChIKey

KTXBOOWDLPUROC-UHFFFAOYSA-N

Smiles

n1cccc(c1)C(=O)NC[C@@H](NC(c1cccnc1)=O)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1500mg/kg (1500mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
mouse LD unreported > 1gm/kg (1000mg/kg)   European Patent Application. Vol. #0029602,
mouse LD50 intravenous 590mg/kg (590mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
rat LD50 intravenous 840mg/kg (840mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,