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Substance Name: Levocabastine hydrochloride [USAN:USP]
RN: 79547-78-7
UNII: 124XMA6YEI
InChIKey: OICFWWJHIMKBCD-VALQNVSPSA-N

Classification Code

  • Antihistaminic

Molecular Formula

  • C26-H29-F-N2-O2.Cl-H

Molecular Weight

  • 456.986
 
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Names and Synonyms

Name of Substance

  • Levocabastine
  • Levocabastine hydrochloride [USAN:USP]

Synonyms

  • (-)-trans-1-(cis-4-Cyano-4-(p-fluorophenyl)cyclohexyl)-3-methyl-4-phenylisonipecotic acid monohydrochloride
  • Levocabastine HCl
  • Levocabastine hydrochloride
  • Livostin
  • R 50,547
  • UNII-124XMA6YEI

Systematic Names

  • 4-Piperidinecarboxylic acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, monohydrochloride, (-)-(1(cis),3alpha,4beta)-
  • 4-Piperidinecarboxylic acid, 1-(cis-4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, monohydrochloride, (3S,4R)-

Registry Numbers

CAS Registry Number

  • 79547-78-7

FDA UNII

  • 124XMA6YEI

Related Registry Number

  • 79516-68-0 (Parent)

System Generated Number

  • 0079547787

Molecular Formulas

Molecular Formula

  • C26-H29-F-N2-O2.Cl-H

Molecular Formula Fragments

  • C26-H29-F-N2-O2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C26H29FN2O2.ClH/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20;/h2-10,19,23H,11-17H2,1H3,(H,30,31);1H/t19-,23-,25-,26-;/m1./s1

InChIKey

OICFWWJHIMKBCD-VALQNVSPSA-N

Smiles

C[C@H]1[C@@](CCN(C1)[C@H]2CC[C@@](CC2)(c3ccc(cc3)F)C#N)(C(=O)O)c4ccccc4.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 2560mg/kg (2560mg/kg) CARDIAC: OTHER CHANGES

BLOOD: HEMORRHAGE
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 1661, 2000.
rat LD50 oral > 2560mg/kg (2560mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 1661, 2000.