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Substance Name: Sertraline [INN:BAN]
RN: 79617-96-2
UNII: QUC7NX6WMB
InChIKey: VGKDLMBJGBXTGI-SJCJKPOMSA-N
Note
- A selective serotonin uptake inhibitor that is used in the treatment of depression.
Molecular Formula
- C17-H17-Cl2-N
Molecular Weight
- 306.2343
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antidepressive Agents
- Central Nervous System Agents
- Drug / Therapeutic Agent
- Human Data
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Uptake Inhibitors
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Links to Resources
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Names and Synonyms
Name of Substance
- Sertraline
- Sertraline [INN:BAN]
MeSH Heading
- Sertraline
Synonyms
- (1S-cis)-1,2,3,4-Tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamine
- BRN 5753709
- Cp 51974
- HSDB 7037
- Sertralina
- Sertralina [Spanish]
- Sertraline
- Sertralinum
- Sertralinum [Latin]
- UNII-QUC7NX6WMB
Systematic Names
- 1-Naphthalenamine, 1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-, (1S-cis)-
- 1-Naphthalenamine, 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-, (1S,4S)-
Registry Numbers
CAS Registry Number
- 79617-96-2
FDA UNII
- QUC7NX6WMB
Related Registry Number
- 79559-97-0 (Hydrochloride)
System Generated Number
- 0079617962
Structure Descriptors
InChI
1S/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17-/m0/s1InChIKey
VGKDLMBJGBXTGI-SJCJKPOMSA-NSmiles
CN[C@H]1CC[C@H](c2c1cccc2)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| man | TDLo | oral | 5714ug/kg/9D- (5.714mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) | Journal of Clinical Psychiatry. Vol. 55, Pg. 316, 1994. |
| man | TDLo | oral | 3571mg/kg/5D- (3571mg/kg) | American Journal of Psychiatry. Vol. 152, Pg. 809, 1995. | |
| man | TDLo | oral | 3571mg/kg/5D- (3571mg/kg) | ENDOCRINE: ANTIDIURESIS | American Journal of Psychiatry. Vol. 152, Pg. 809, 1995. |
| women | TDLo | oral | 2mg/kg/2D-I (2mg/kg) | BEHAVIORAL: EXCITEMENT | Journal of the American Academy of Child and Adolescent Psychiatry. Vol. 35, Pg. 975, 1996. |
| women | TDLo | oral | 6mg/kg/4D-I (6mg/kg) | ENDOCRINE: ANTIDIURESIS BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | American Journal of Psychiatry. Vol. 152, Pg. 809, 1995. |
| women | TDLo | oral | 10500ug/kg/3W (10.5mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) ENDOCRINE: ANTIDIURESIS | Annals of Internal Medicine. Vol. 123, Pg. 811, 1995. |
| women | TDLo | oral | 28mg/kg/4W-I (28mg/kg) | BLOOD: AGRANULOCYTOSIS | Postgraduate Medical Journal. Vol. 72, Pg. 446, 1996. |
| women | TDLo | oral | 63mg/kg/10W-I (63mg/kg) | BLOOD: TUMORS | American Journal of Psychiatry. Vol. 153, Pg. 443, 1996. |
| women | TDLo | oral | 70mg/kg/7W-I (70mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | American Journal of Psychiatry. Vol. 153, Pg. 732, 1996. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| log P (octanol-water) | 5.290 | (none) | EST | |
| Atmospheric OH Rate Constant | 9.82E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.