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Substance Name: Loratadine [USAN:USP:INN:BAN]
RN: 79794-75-5
UNII: 7AJO3BO7QN
InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N
Note
- A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.
Molecular Formula
- C22-H23-Cl-N2-O2
Molecular Weight
- 382.8887
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Physical Properties
Classification Codes
- Anti-Allergic Agents
- Antihistaminic
- Antipruritics
- Dermatologic Agents
- Histamine Agents
- Histamine Antagonists
- Histamine H1 Antagonists
- Histamine H1 Antagonists, Non-Sedating
- Neurotransmitter Agents
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Names and Synonyms
Name of Substance
- Loratadine
- Loratadine [USAN:USP:INN:BAN]
MeSH Heading
- Loratadine
Synonyms
- 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
- Aerotina
- Alarin
- Alavert
- Alerpriv
- Allertidin
- Anhissen
- Bactimicina allergy
- Bedix Loratadina
- Biloina
- Bonalerg
- Children's Claritin
- Civeran
- Claratyne
- Claratyne Cold
- Claratyne Decongestant
- Clarinase
- Clarinase Reperabs
- Claritin
- Claritin Hives Relief
- Claritin Hives Relief Reditab
- Claritin reditab
- Claritin Reditabs
- Claritine
- Clarityn
- Clarityne
- Clarityne Dy Repetabs
- Clarityne-D
- Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate
- Fristamin
- Histaloran
- HSDB 3578
- Lergy
- Lertamine
- Lesidas
- Lisino
- Loracert
- Loradex
- Loradif
- Loranox
- Lorantis
- Lorastine
- Loratadina
- Loratadina [Spanish]
- Loratadine
- Loratadine Redidose
- Loratadinum
- Loratadinum [Latin]
- Loratyne
- Loraver
- Lorfast
- Loritine
- Lowadina
- NSC 721075
- NSC 758628
- Nularef
- Optimin
- Polaratyne
- Pylor
- Restamine
- Rhinase
- Rinomex
- Sanelor
- Sch 29851
- Sensibit
- Sinhistan Dy
- Sohotin
- Tadine
- Talorat Dy
- Topcare childrens allergy relief
- UNII-7AJO3BO7QN
- Velodan
- Versal
- Zeos
Systematic Name
- 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
Mixture Name
- Claritin D
Registry Numbers
CAS Registry Number
- 79794-75-5
FDA UNII
- 7AJO3BO7QN
System Generated Number
- 0079794755
Structure Descriptors
InChI
InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3InChIKey
JCCNYMKQOSZNPW-UHFFFAOYSA-NSmiles
CCOC(=O)Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | 134-136 | deg C | EXP | |
| log P (octanol-water) | 5.2 | (none) | EXP | |
| Water Solubility | 0.011 | mg/L | 25 | EST |
| Vapor Pressure | 1.56E-09 | mm Hg | 25 | EST |
| Henry's Law Constant | 3.19E-13 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 1.43E-10 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.