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Substance Name: Loratadine [USAN:USP:INN:BAN]
RN: 79794-75-5
UNII: 7AJO3BO7QN
InChIKey: JCCNYMKQOSZNPW-UHFFFAOYSA-N

Note

  • A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.

Molecular Formula

  • C22-H23-Cl-N2-O2

Molecular Weight

  • 382.8887
 

Classification Codes

  • Anti-Allergic Agents
  • Antihistaminic
  • Antipruritics
  • Dermatologic Agents
  • Histamine Agents
  • Histamine Antagonists
  • Histamine H1 Antagonists
  • Histamine H1 Antagonists, Non-Sedating
  • Neurotransmitter Agents

Names and Synonyms

Name of Substance

  • Loratadine
  • Loratadine [USAN:USP:INN:BAN]

MeSH Heading

  • Loratadine

Synonyms

  • 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester
  • Aerotina
  • Alarin
  • Alavert
  • Alerpriv
  • Allertidin
  • Anhissen
  • Bactimicina allergy
  • Bedix Loratadina
  • Biloina
  • Bonalerg
  • Children's Claritin
  • Civeran
  • Claratyne
  • Claratyne Cold
  • Claratyne Decongestant
  • Clarinase
  • Clarinase Reperabs
  • Claritin
  • Claritin Hives Relief
  • Claritin Hives Relief Reditab
  • Claritin reditab
  • Claritin Reditabs
  • Claritine
  • Clarityn
  • Clarityne
  • Clarityne Dy Repetabs
  • Clarityne-D
  • Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-1-piperidinecarboxylate
  • Fristamin
  • Histaloran
  • HSDB 3578
  • Lergy
  • Lertamine
  • Lesidas
  • Lisino
  • Loracert
  • Loradex
  • Loradif
  • Loranox
  • Lorantis
  • Lorastine
  • Loratadina
  • Loratadina [Spanish]
  • Loratadine
  • Loratadine Redidose
  • Loratadinum
  • Loratadinum [Latin]
  • Loratyne
  • Loraver
  • Lorfast
  • Loritine
  • Lowadina
  • Nularef
  • Optimin
  • Polaratyne
  • Pylor
  • Restamine
  • Rhinase
  • Rinomex
  • Sanelor
  • Sch 29851
  • Sensibit
  • Sinhistan Dy
  • Sohotin
  • Tadine
  • Talorat Dy
  • Topcare childrens allergy relief
  • UNII-7AJO3BO7QN
  • Velodan
  • Versal
  • Zeos

Systematic Name

  • 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo(5,6)cyclohepta(1,2-b)pyridin-11-ylidene)-, ethyl ester

Mixture Name

  • Claritin D

Registry Numbers

CAS Registry Number

  • 79794-75-5

FDA UNII

  • 7AJO3BO7QN

System Generated Number

  • 0079794755

Structure Descriptors

InChI

1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChIKey

JCCNYMKQOSZNPW-UHFFFAOYSA-N

Smiles

CCOC(=O)N1CCC(=C2c3ccc(cc3CCc4c2nccc4)Cl)CC1

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 134-136 deg C   EXP
log P (octanol-water) 5.2 (none)   EXP
Water Solubility 0.011 mg/L 25 EST
Vapor Pressure 1.56E-09 mm Hg 25 EST
Henry's Law Constant 3.19E-13 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.43E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.