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Substance Name: Idazoxan [INN:BAN]
RN: 79944-58-4
UNII: Y310PA316B
InChIKey: HPMRFMKYPGXPEP-UHFFFAOYSA-N

Note

  • A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.

Molecular Formula

  • C11-H12-N2-O2

Molecular Weight

  • 204.228
 

Classification Codes

  • Adrenergic Agents
  • Adrenergic alpha-2 Receptor Antagonists
  • Adrenergic alpha-Antagonists
  • Adrenergic Antagonists
  • Drug / Therapeutic Agent
  • Neurotransmitter Agents
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Names and Synonyms

Name of Substance

  • Idazoxan
  • Idazoxan [INN:BAN]

MeSH Heading

  • Idazoxan

Synonyms

  • 2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole
  • Idazoxan
  • Idazoxane
  • Idazoxane [French]
  • Idazoxano
  • Idazoxano [Spanish]
  • Idazoxanum
  • Idazoxanum [Latin]
  • UNII-Y310PA316B

Systematic Names

  • (+-)-2-(1,4-Benzodioxan-2-yl)-2-imidazoline
  • 1H-Imidazole, 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-

Registry Numbers

CAS Registry Number

  • 79944-58-4

FDA UNII

  • Y310PA316B

System Generated Number

  • 0079944584

Structure Descriptors

InChI

1S/C11H12N2O2/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10H,5-7H2,(H,12,13)

InChIKey

HPMRFMKYPGXPEP-UHFFFAOYSA-N

Smiles

C=1([C@@H]2Oc3c(cccc3)OC2)NCCN1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 85mg/kg (85mg/kg)   European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 25, Pg. 557, 1990.