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Substance Name: Sulfamethoxypyridazine [USP:INN:BAN]
RN: 80-35-3
UNII: T034E4NS2Z
InChIKey: VLYWMPOKSSWJAL-UHFFFAOYSA-N

Note

  • A sulfanilamide antibacterial agent.

Molecular Formula

  • C11-H12-N4-O3-S

Molecular Weight

  • 280.3068
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Sulfamethoxypyridazine
  • Sulfamethoxypyridazine [USP:INN:BAN]

MeSH Heading

  • Sulfamethoxypyridazine

Synonyms

  • 3-(p-Aminobenzenesulfamido)-6-methoxypyridazine
  • 3-Methoxy-6-sulfanylamidopyridazine
  • 3-p-Aminobenzenesulphonamido-6-methoxypyridazine
  • 3-Sulfa-6-methoxypyridazine
  • 3-Sulfanilamide-6-methoxypyridazine
  • 3-Sulfanilamido-6-methoxypyridazine
  • 4-Amino-N-(6-methoxy-3-pyridazinyl)benzolsulfonamid
  • 5-25-12-00424 (Beilstein Handbook Reference)
  • 6-Methoxy-3-sulfanilamidopyridazine
  • 6-Sulfanilamido-3-methoxypyridazine
  • Altezol
  • BRN 0277076
  • CL 13494
  • Davosin
  • Depovernil
  • Durox
  • EINECS 201-272-5
  • Kinex
  • Kynex
  • Lederkyn
  • Lentac
  • Lisulfen
  • Longin
  • Medicel
  • Midicel
  • Midikel
  • Myasul
  • N(sup 1)-(6-Methoxy-3-pyridazinyl)sulfanilamide
  • Opinsul
  • Paramid
  • Paramid Supra
  • Petrisul
  • Piridolo
  • Quinoseptyl
  • Retamid
  • Retasulfin
  • RP 7522
  • Slosul
  • SMOP
  • Solfametossipiridazina
  • Solfametossipiridazina [DCIT]
  • Spofadazine
  • Sulfalex
  • Sulfamethoxipyridazinum
  • Sulfamethoxypyridazine
  • Sulfamethoxypyridazinum
  • Sulfamethoxypyridazinum [INN-Latin]
  • Sulfametoxipiridazina
  • Sulfametoxipiridazina [INN-Spanish]
  • Sulfametoxipiridazine
  • Sulfapyridazine
  • Sulfdurazin
  • Sulfozona
  • Sulphamethoxypyridazine
  • Sultirene
  • UNII-T034E4NS2Z
  • Vinces

Systematic Names

  • 4-Amino-N-(6-methoxy-3-pyridazinyl)-benzenesulfonamide (9CI)
  • Benzenesulfonamide, 4-amino-N-(6-methoxy-3-pyridazinyl)-
  • N(sup 1)-(6-Methoxy-3-pyridazinyl)sulfanilamide
  • Sulfamethoxypyridazine
  • Sulfanilamide, N(sup 1)-(6-methoxy-3-pyridazinyl)-

Registry Numbers

CAS Registry Number

  • 80-35-3

FDA UNII

  • T034E4NS2Z

System Generated Number

  • 0000080353

Structure Descriptors

InChI

1S/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15)

InChIKey

VLYWMPOKSSWJAL-UHFFFAOYSA-N

Smiles

c1(S(=O)(=O)Nc2ccc(nn2)OC)ccc(cc1)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 1800mg/kg (1800mg/kg)   "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964.
guinea pig LD50 oral 2810mg/kg (2810mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: MUSCLE WEAKNESS
Farmakologiya i Toksikologiya Vol. 37, Pg. 616, 1974.
mouse LD50 intraperitoneal 1200mg/kg (1200mg/kg) PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Russian Pharmacology and Toxicology Vol. 37, Pg. 223, 1974.
mouse LD50 intravenous 1gm/kg (1000mg/kg)   "Experimental Chemotherapy, Volume II," Schnitzer, R.J., and F. Hawking, eds. Academic Press New York, 1964Vol. 2, Pg. 249, 1964.
mouse LD50 oral 1700mg/kg (1700mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 612, 1960.
mouse LD50 subcutaneous 4500mg/kg (4500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 10, Pg. 440, 1960.
rabbit LD50 oral 2810mg/kg (2810mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Farmakologiya i Toksikologiya Vol. 37, Pg. 616, 1974.
rat LD50 oral 2739mg/kg (2739mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 459, 1961.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 182.5 deg C   EXP
pKa Dissociation Constant 6.7 (none)   EXP
log P (octanol-water) 0.32 (none)   EXP
Water Solubility 147 mg/L 37 EXP
Vapor Pressure 5.65E-10 mm Hg 25 EST
Henry's Law Constant 2.37E-14 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.82E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.