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Substance Name: Methyl methacrylate
RN: 80-62-6
UNII: 196OC77688
InChIKey: VVQNEPGJFQJSBK-UHFFFAOYSA-N

Note

  • The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.

Molecular Formula

  • C5-H8-O2

Molecular Weight

  • 100.116
 

Classification Codes

Classification Codes

  • Bone Cements
  • Human Data
  • Mutation Data
  • Reproductive Effect
  • Resins, Synthetic
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • Reportable Quantity (RQ) = 1000 lb
  • TWA (50 ppm) STEL (100 ppm); Sensitizer; Not classifiable as a human carcinogen
  • TWA 100 ppm (410 mg/m3)

Names and Synonyms

Name of Substance

  • Methyl methacrylate

MeSH Heading

  • Methylmethacrylate

Synonyms

  • 2-(Methoxycarbonyl)-1-propene
  • 2-Methyl-2-propenoic acid methyl ester
  • 2-Methylacrylic acid, methyl ester
  • 2-Propenoic acid, 2-methyl-, methyl ester
  • 4-02-00-01519 (Beilstein Handbook Reference)
  • Acryester M
  • Acrylic acid, 2-methyl-, methyl ester
  • AI3-24946
  • BRN 0605459
  • CCRIS 1364
  • Cranioplast
  • Diakon
  • EC 201-297-1
  • EINECS 201-297-1
  • HSDB 195
  • Kallocryl A
  • Metakrylan metylu
  • Metakrylan metylu [Polish]
  • Metaplex
  • Methacrylate de methyle
  • Methacrylate de methyle [French]
  • Methacrylic acid, methyl ester
  • Methacrylsaeuremethyl ester
  • Methacrylsaeuremethyl ester [German]
  • Methyl 2-methyl-2-propenoate
  • Methyl 2-methylpropenoate
  • Methyl methacrylate
  • Methyl methacrylate monomer
  • Methyl methylacrylate
  • Methyl-methacrylat
  • Methyl-methacrylat [German]
  • Methylester kyseliny methakrylove
  • Methylester kyseliny methakrylove [Czech]
  • Methylmethacrylaat
  • Methylmethacrylaat [Dutch]
  • Metil metacrilato
  • Metil metacrilato [Italian]
  • MMA
  • monocite Methacrylate monomer
  • NCI-C50680
  • NSC 4769
  • Pegalan
  • RCRA waste number U162
  • Simplex P
  • TEB 3K
  • UNII-196OC77688

Systematic Names

  • 2-Propenoic acid, 2-methyl-, methyl ester
  • Methacrylic acid, methyl ester
  • Methyl methacrylate

Superlist Names

  • 2-Propenoic acid, 2-methyl-, methyl ester
  • Methacrylic acid methyl ester
  • Methyl methacrylate
  • Methyl methacrylate monomer, inhibited
  • Methyl methacrylate monomer, inhibited [UN1247] [Flammable liquid]
  • RCRA waste no. U162
  • UN1247

Registry Numbers

CAS Registry Number

  • 80-62-6

FDA UNII

  • 196OC77688

Other Registry Numbers

  • 1196968-39-4
  • 1227277-87-3
  • 1451188-71-8
  • 1453489-95-6
  • 162221-54-7
  • 211862-43-0
  • 220713-32-6
  • 874217-13-7

System Generated Number

  • 0000080626

Structure Descriptors

InChI

1S/C5H8O2/c1-4(2)5(6)7-3/h1H2,2-3H3

InChIKey

VVQNEPGJFQJSBK-UHFFFAOYSA-N

Smiles

C(C(C)=C)(OC)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo subcutaneous 7mL/kg (7mL/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI
National Technical Information Service. Vol. OTS0520933,
dog LCLo inhalation 41200mg/m3/3H (41200mg/m3) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Industrial Medicine. Vol. 14, Pg. 292, 1945.
dog LD50 oral 4725mg/kg (4725mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Industrial Medicine. Vol. 14, Pg. 292, 1945.
dog LD50 subcutaneous 4252mg/kg (4252mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.
dog LDLo intravenous 120uL/kg (0.12mL/kg)   Journal of Pharmaceutical Sciences. Vol. 63, Pg. 376, 1974.
guinea pig LCLo inhalation 19000mg/m3/5H (19000mg/m3) BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941.
guinea pig LD50 intraperitoneal 1890mg/kg (1890mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.
guinea pig LD50 oral 5954mg/kg (5954mg/kg) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ATAXIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Industrial Medicine. Vol. 14, Pg. 292, 1945.
guinea pig LD50 subcutaneous 5954mg/kg (5954mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.
human TCLo inhalation 60mg/m3 (60mg/m3) BEHAVIORAL: SLEEP

BEHAVIORAL: EXCITEMENT

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 1, Pg. 56, 1957.
human TCLo inhalation 125ppm (125ppm) BEHAVIORAL: SLEEP

BEHAVIORAL: EXCITEMENT

BEHAVIORAL: ANOREXIA (HUMAN
Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 19(10), Pg. 25, 1954.
mammal (species unspecified) LC50 inhalation 20gm/m3 (20000mg/m3)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986.
mouse LC50 inhalation 18500mg/m3/2H (18500mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(6), Pg. 5, 1976.
mouse LD50 intraperitoneal 945mg/kg (945mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.
mouse LD50 oral 3625mg/kg (3625mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(4), Pg. 6, 1976.
mouse LD50 subcutaneous 5954mg/kg (5954mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.
rabbit LCLo inhalation 17500mg/m3/4. (17500mg/m3) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941.
rabbit LD50 oral 8700mg/kg (8700mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(4), Pg. 6, 1976.
rabbit LD50 skin > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" National Technical Information Service. Vol. OTS0544282,
rabbit LDLo subcutaneous 14mL/kg (14mL/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

KIDNEY, URETER, AND BLADDER: HEMATURIA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0520933,
rat LC50 inhalation 78000mg/m3/4H (78000mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(6), Pg. 5, 1976.
rat LD50 intraperitoneal 1328mg/kg (1328mg/kg)   Journal of Dental Research. Vol. 51, Pg. 1632, 1972.
rat LD50 oral 7872mg/kg (7872mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: COMA

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941.
rat LD50 subcutaneous 7088mg/kg (7088mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Industrial Medicine. Vol. 14, Pg. 292, 1945.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -4.80E+01 deg C   EXP
Boiling Point 100.5 deg C   EXP
log P (octanol-water) 1.38 (none)   EXP
Water Solubility 1.50E+04 mg/L 25 EXP
Vapor Pressure 38.5 mm Hg 25 EXP
Henry's Law Constant 3.19E-04 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 2.60E-11 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.