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Substance Name: Methyl methacrylate
RN: 80-62-6
UNII: 196OC77688
InChIKey: VVQNEPGJFQJSBK-UHFFFAOYSA-N
Note
- The methyl ester of methacrylic acid. It polymerizes easily to form POLYMETHYL METHACRYLATE. It is used as a bone cement.
Molecular Formula
- C5-H8-O2
Molecular Weight
- 100.116
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Bone Cements
- Human Data
- Mutation Data
- Reproductive Effect
- Resins, Synthetic
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 3
- Reportable Quantity (RQ) = 1000 lb
- TWA (50 ppm) STEL (100 ppm); Sensitizer; Not classifiable as a human carcinogen
- TWA 100 ppm (410 mg/m3)
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Other Resources (Internet Locators)
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Names and Synonyms
Name of Substance
- Methyl methacrylate
MeSH Heading
- Methylmethacrylate
Synonyms
- 2-(Methoxycarbonyl)-1-propene
- 2-Methyl-2-propenoic acid methyl ester
- 2-Methylacrylic acid, methyl ester
- 2-Propenoic acid, 2-methyl-, methyl ester
- 4-02-00-01519 (Beilstein Handbook Reference)
- Acryester M
- Acrylic acid, 2-methyl-, methyl ester
- AI3-24946
- BRN 0605459
- CCRIS 1364
- Cranioplast
- Diakon
- EC 201-297-1
- EINECS 201-297-1
- HSDB 195
- Kallocryl A
- Metakrylan metylu
- Metakrylan metylu [Polish]
- Metaplex
- Methacrylate de methyle
- Methacrylate de methyle [French]
- Methacrylic acid, methyl ester
- Methacrylsaeuremethyl ester
- Methacrylsaeuremethyl ester [German]
- Methyl 2-methyl-2-propenoate
- Methyl 2-methylpropenoate
- Methyl methacrylate
- Methyl methacrylate monomer
- Methyl methylacrylate
- Methyl-methacrylat
- Methyl-methacrylat [German]
- Methylester kyseliny methakrylove
- Methylester kyseliny methakrylove [Czech]
- Methylmethacrylaat
- Methylmethacrylaat [Dutch]
- Metil metacrilato
- Metil metacrilato [Italian]
- MMA
- monocite Methacrylate monomer
- NCI-C50680
- NSC 4769
- Pegalan
- RCRA waste number U162
- Simplex P
- TEB 3K
- UNII-196OC77688
Systematic Names
- 2-Propenoic acid, 2-methyl-, methyl ester
- Methacrylic acid, methyl ester
- Methyl methacrylate
Superlist Names
- 2-Propenoic acid, 2-methyl-, methyl ester
- Methacrylic acid methyl ester
- Methyl methacrylate
- Methyl methacrylate monomer, inhibited
- Methyl methacrylate monomer, inhibited [UN1247] [Flammable liquid]
- RCRA waste no. U162
- UN1247
Registry Numbers
CAS Registry Number
- 80-62-6
FDA UNII
- 196OC77688
Other Registry Numbers
- 1196968-39-4
- 1227277-87-3
- 1451188-71-8
- 1453489-95-6
- 162221-54-7
- 211862-43-0
- 220713-32-6
- 874217-13-7
System Generated Number
- 0000080626
Structure Descriptors
InChI
InChI=1S/C5H8O2/c1-4(2)5(6)7-3/h1H2,2-3H3InChIKey
VVQNEPGJFQJSBK-UHFFFAOYSA-NSmiles
COC(=O)Toxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | subcutaneous | 7mL/kg (7mL/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE KIDNEY, URETER, AND BLADDER: CHANGES PRIMARILY IN GLOMERULI | National Technical Information Service. Vol. OTS0520933, |
| dog | LCLo | inhalation | 41200mg/m3/3H (41200mg/m3) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| dog | LD50 | oral | 4725mg/kg (4725mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| dog | LD50 | subcutaneous | 4252mg/kg (4252mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| dog | LDLo | intravenous | 120uL/kg (0.12mL/kg) | Journal of Pharmaceutical Sciences. Vol. 63, Pg. 376, 1974. | |
| guinea pig | LCLo | inhalation | 19000mg/m3/5H (19000mg/m3) | BEHAVIORAL: COMA BEHAVIORAL: MUSCLE WEAKNESS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941. |
| guinea pig | LD50 | intraperitoneal | 1890mg/kg (1890mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| guinea pig | LD50 | oral | 5954mg/kg (5954mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: ATAXIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| guinea pig | LD50 | subcutaneous | 5954mg/kg (5954mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| human | TCLo | inhalation | 60mg/m3 (60mg/m3) | BEHAVIORAL: SLEEP BEHAVIORAL: EXCITEMENT VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 1, Pg. 56, 1957. |
| human | TCLo | inhalation | 125ppm (125ppm) | BEHAVIORAL: SLEEP BEHAVIORAL: EXCITEMENT BEHAVIORAL: ANOREXIA (HUMAN | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 19(10), Pg. 25, 1954. |
| mammal (species unspecified) | LC50 | inhalation | 20gm/m3 (20000mg/m3) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 51(5), Pg. 61, 1986. | |
| mouse | LC50 | inhalation | 18500mg/m3/2H (18500mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(6), Pg. 5, 1976. | |
| mouse | LD50 | intraperitoneal | 945mg/kg (945mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| mouse | LD50 | oral | 3625mg/kg (3625mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(4), Pg. 6, 1976. | |
| mouse | LD50 | subcutaneous | 5954mg/kg (5954mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
| rabbit | LCLo | inhalation | 17500mg/m3/4. (17500mg/m3) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: COMA BEHAVIORAL: MUSCLE WEAKNESS | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941. |
| rabbit | LD50 | oral | 8700mg/kg (8700mg/kg) | Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 41(4), Pg. 6, 1976. | |
| rabbit | LD50 | skin | > 5gm/kg (5000mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" | National Technical Information Service. Vol. OTS0544282, |
| rabbit | LDLo | subcutaneous | 14mL/kg (14mL/kg) | LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES KIDNEY, URETER, AND BLADDER: HEMATURIA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | National Technical Information Service. Vol. OTS0520933, |
| rat | LC50 | inhalation | 78000mg/m3/4H (78000mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 20(6), Pg. 5, 1976. | |
| rat | LD50 | intraperitoneal | 1328mg/kg (1328mg/kg) | Journal of Dental Research. Vol. 51, Pg. 1632, 1972. | |
| rat | LD50 | oral | 7872mg/kg (7872mg/kg) | LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: COMA BEHAVIORAL: MUSCLE WEAKNESS | Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 343, 1941. |
| rat | LD50 | subcutaneous | 7088mg/kg (7088mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | Industrial Medicine. Vol. 14, Pg. 292, 1945. |
Physical Properties
| Physical Property | Value | Units | Temp (deg C) | Source |
|---|---|---|---|---|
| Melting Point | -4.80E+01 | deg C | EXP | |
| Boiling Point | 100.5 | deg C | EXP | |
| log P (octanol-water) | 1.38 | (none) | EXP | |
| Water Solubility | 1.50E+04 | mg/L | 25 | EXP |
| Vapor Pressure | 38.5 | mm Hg | 25 | EXP |
| Henry's Law Constant | 3.19E-04 | atm-m3/mole | 25 | EST |
| Atmospheric OH Rate Constant | 2.60E-11 | cm3/molecule-sec | 25 | EXP |
Physical property data is provided to ChemIDplus by SRC, Inc.