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Substance Name: Ipecac [USP]
RN: 8012-96-2
UNII: 62I3C8233L

Note

  • A syrup made from the dried rhizomes of two different species, CEPHAELIS ipecacuanha and C. acuminata. They contain EMETINE, cephaeline, psychotrine and other ISOQUINOLINES. Ipecac syrup is used widely as an emetic acting both locally on the gastric mucosa and centrally on the chemoreceptor trigger zone.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Autonomic Agents
  • Central Nervous System Agents
  • Emetic
  • Emetics
  • Gastrointestinal Agents
  • Human Data
  • Peripheral Nervous System Agents

Names and Synonyms

Name of Substance

  • Ipecac
  • Ipecac [USP]

MeSH Heading

  • Ipecac

Synonyms

  • EINECS 232-385-8
  • Ipecac
  • Ipecacuanha
  • Ipsatol
  • Syrup of ipecac, U.S.P
  • UNII-62I3C8233L

Systematic Names

  • Ipecac
  • Ipecac syrup

Registry Numbers

CAS Registry Number

  • 8012-96-2

FDA UNII

  • 62I3C8233L

Other Registry Numbers

  • 8047-07-2
  • 8052-61-7
  • 8060-27-3

System Generated Number

  • 0008012962

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral 5gm/kg (5000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
"Management of the Poisoned Patient," Rumack, B.H., and A.R. Temple, eds., Princeton, NJ, Science Press, 1977Vol. -, Pg. 175, 1977.
human TDLo oral 70mg/kg (70mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING Journal of Pharmaceutical Sciences. Vol. 65, Pg. 1398, 1976.
man TDLo oral 214mg/kg (214mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

GASTROINTESTINAL: NAUSEA OR VOMITING
Southern Medical Journal. Vol. 77, Pg. 804, 1984.
rat LDLo oral 510uL/kg (0.51mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 27, Pg. 891, 1999.
women LDLo oral 113mg/kg/13W- (113mg/kg) CARDIAC: CHANGE IN RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
JAMA, Journal of the American Medical Association. Vol. 243, Pg. 1927, 1980.