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Substance Name: Transglutaminases
RN: 80146-85-6

Note

  • Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.
 
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Names and Synonyms

Name of Substance

  • Transglutaminases

MeSH Heading

  • Transglutaminases

Synonyms

  • Gamma-Glutamyltransferases, Glutaminyl-Peptide
  • gamma-Glutamyltransferases, Protein-Glutamine
  • Glutaminyl Peptide Gamma Glutamyltransferases
  • Glutaminyl-Peptide Gamma-Glutamyltransferases
  • Protein Glutamine gamma Glutamyltransferases
  • Protein-Glutamine gamma-Glutamyltransferases

Systematic Name

  • Protein-glutamine:amine gamma-glutamyltransferase

Registry Numbers

CAS Registry Number

  • 80146-85-6

System Generated Number

  • 0080146856

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD oral > 2gm/kg (2000mg/kg)   International Journal of Toxicology. Vol. 17, Pg. 703, 1998.
rat LD oral > 2gm/kg (2000mg/kg)   International Journal of Toxicology. Vol. 17, Pg. 703, 1998.