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Substance Name: Conestat alfa [INN]
RN: 80295-38-1
UNII: 5QS67N4551


  • An endogenous 105-kDa plasma glycoprotein produced primarily by the LIVER and MONOCYTES. It inhibits a broad spectrum of proteases, including the COMPLEMENT C1R and the COMPLEMENT C1S proteases of the CLASSICAL COMPLEMENT PATHWAY, and the MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. C1-INH-deficient individuals suffer from HEREDITARY ANGIOEDEMA TYPES I AND II.
  • Recombinant analog.

Molecular Formula

  • Unspecified

Classification Codes

  • Antiviral (COVID-19)
  • Complement Inactivating Agents
  • Immunologic Factors
  • Immunosuppressive Agents

Names and Synonyms

Name of Substance

  • Complement C1 Inhibitor Protein
  • Conestat alfa [INN]

MeSH Heading

  • Complement C1 Inhibitor Protein


  • Berinert
  • Berinert P
  • Bicizar
  • C1 esterase inhibitor
  • C1-INH
  • C1INH
  • C1INH proteins
  • Conestat alfa
  • Constat alfa
  • Gene C1INH protein
  • Human C1-esterase inhibitor
  • Rhucin
  • Ruconest
  • Serpin G1
  • UNII-5QS67N4551

Registry Numbers

CAS Registry Number

  • 80295-38-1


  • 5QS67N4551

Other Registry Number

  • 81295-50-3

System Generated Number

  • 0080295381