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Substance Name: Complement factor H
RN: 80295-65-4


  • An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).

Molecular Formula

  • Unspecified

Classification Codes

  • Complement Inactivating Agents
  • Immunologic Factors
  • Immunosuppressive Agents
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Names and Synonyms

Name of Substance

  • Complement factor H

MeSH Heading

  • Complement factor H


  • Factor H

Systematic Name

  • Complement factor H

Registry Numbers

CAS Registry Number

  • 80295-65-4

System Generated Number

  • 0080295654