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Substance Name: Digitalis [USP]
RN: 8031-42-3
UNII: F1T8QT9U8B

Note

  • A genus of toxic herbaceous Eurasian plants of the SCROPHULARIACEAE which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.

Molecular Formula

  • Unspecified
 

Classification Codes

  • Cardiotonic
  • Human Data
  • Natural Product

Names and Synonyms

Name of Substance

  • Digitalis [USP]

Synonyms

  • Digifortis
  • Digiglusin
  • Digitalin (pharmaceutical)
  • Digitalis
  • Digitalis purpurea, leaf
  • Digitalone
  • Digitannoid
  • Digitol
  • Folium Digitalis purpureae
  • Foxglove
  • UNII-F1T8QT9U8B

Systematic Names

  • Digitalis
  • Digitol

Registry Numbers

CAS Registry Number

  • 8031-42-3

FDA UNII

  • F1T8QT9U8B

Other Registry Number

  • 8031-43-4

System Generated Number

  • 0008031423

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 oral 244mg/kg (244mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 607, 1955.
cat LDLo intraarterial 30gm/kg (30000mg/kg)   Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 131, Pg. 171, 1928.
cat LDLo intravenous 62mg/kg (62mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 44, Pg. 607, 1955.
man LDLo unreported 29mg/kg (29mg/kg)   "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
man TDLo intravenous 12ug/kg (0.012mg/kg) BEHAVIORAL: IRRITABILITY

CARDIAC: OTHER CHANGES

SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
JAMA, Journal of the American Medical Association. Vol. 241, Pg. 164, 1979.
mouse LDLo intravenous 200mg/kg (200mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: PULSE RATE
Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 82, Pg. 1, 1917.
pigeon LD50 intraperitoneal 220mg/kg (220mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 96, 1962.
pigeon LDLo intravenous 670mg/kg (670mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 14, Pg. 96, 1962.
rat LDLo intraperitoneal 50mg/kg (50mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.